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Serum levels of interleukin-6 as a prognostic factor in advanced non-small cell lung cancer.

  • Authors:
    • F De Vita
    • M Orditura
    • A Auriemma
    • S Infusino
    • A Roscigno
    • G Catalano

  • View Affiliations

  • Published online on: May 1, 1998     https://doi.org/10.3892/or.5.3.649
  • Pages: 649-701
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Abstract

Serum levels of interleukin-6 (IL-6) were evaluated in a group of advanced non-small cell lung cancer (NSCLC) patients using an enzyme-linked immunosorbent assay. The data were related to clinical status and to cisplatin-based chemotherapy response. The mean IL-6 concentrations were higher than the controls (p<0.0001); patients with metastatic tumor had higher levels than those with undisseminated disease (p<0.006). Tumor progression was associated with an increase of IL-6 levels. Patients who responded to chemotherapy had lower serum IL-6 levels compared with unresponsive patients (p<0.0001). These data suggest that NSCLC patients with high levels of IL-6 have a worse clinical outcome and may manifest resistance to cisplatin chemotherapy.

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May-Jun 1998
Volume 5 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
De Vita F, Orditura M, Auriemma A, Infusino S, Roscigno A and Catalano G: Serum levels of interleukin-6 as a prognostic factor in advanced non-small cell lung cancer.. Oncol Rep 5: 649-701, 1998
APA
De Vita, F., Orditura, M., Auriemma, A., Infusino, S., Roscigno, A., & Catalano, G. (1998). Serum levels of interleukin-6 as a prognostic factor in advanced non-small cell lung cancer.. Oncology Reports, 5, 649-701. https://doi.org/10.3892/or.5.3.649
MLA
De Vita, F., Orditura, M., Auriemma, A., Infusino, S., Roscigno, A., Catalano, G."Serum levels of interleukin-6 as a prognostic factor in advanced non-small cell lung cancer.". Oncology Reports 5.3 (1998): 649-701.
Chicago
De Vita, F., Orditura, M., Auriemma, A., Infusino, S., Roscigno, A., Catalano, G."Serum levels of interleukin-6 as a prognostic factor in advanced non-small cell lung cancer.". Oncology Reports 5, no. 3 (1998): 649-701. https://doi.org/10.3892/or.5.3.649