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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May-Jun 1998 Volume 5 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May-Jun 1998 Volume 5 Issue 3

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Article

NM23 gene product expression does not predict lymph node metastases or survival in young patients with colorectal cancer.

  • Authors:
    • S D Heys
    • N Langlois
    • I C Smith
    • L G Walker
    • O Eremin

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Surgical Nutrition and Metabolism Unit, University Medical Buildings, Aberdeen Royal Infirmary, Aberdeen, AB9 2ZD, Scotland, UK.
  • Pages: 735-744
    |
    Published online on: May 1, 1998
       https://doi.org/10.3892/or.5.3.735
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Abstract

NM23 gene product is a putative metastases suppressor gene which has structural homology to a nucleoside diphosphate kinase. Previous studies examining the relationship between NM23 gene product expression and survival in patients with colorectal cancer have revealed conflicting results. However, no study has focused on young patients with colorectal cancer. This study was carried out to determine if expression of the NM23 gene product was correlated with metastatic potential and survival in young patients (45 years and under) with colorectal cancer. Eighty- one patients with colorectal cancer were studied and the presence of the NM23 gene product (H1) was detected using standard immunohistochemical techniques. NM23 gene product expression did not correlate with tumour stage, lymph node involvement by tumour, presence of distant metastases, extramural vascular invasion or degree of tumour differentiation. Independent risk factors for overall survival were: Dukes' stage (p=0.00001) and extramural vascular invasion (p=0.003). NM23 expression was not an independent prognostic indicator (p=0.55). Therefore, NM23 expression does not correlate with existing indicators of tumour aggressiveness and behaviour nor is it an independent predictor of survival in young patients with colorectal cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Heys S, Langlois N, Smith I, Walker L and Eremin O: NM23 gene product expression does not predict lymph node metastases or survival in young patients with colorectal cancer.. Oncol Rep 5: 735-744, 1998.
APA
Heys, S., Langlois, N., Smith, I., Walker, L., & Eremin, O. (1998). NM23 gene product expression does not predict lymph node metastases or survival in young patients with colorectal cancer.. Oncology Reports, 5, 735-744. https://doi.org/10.3892/or.5.3.735
MLA
Heys, S., Langlois, N., Smith, I., Walker, L., Eremin, O."NM23 gene product expression does not predict lymph node metastases or survival in young patients with colorectal cancer.". Oncology Reports 5.3 (1998): 735-744.
Chicago
Heys, S., Langlois, N., Smith, I., Walker, L., Eremin, O."NM23 gene product expression does not predict lymph node metastases or survival in young patients with colorectal cancer.". Oncology Reports 5, no. 3 (1998): 735-744. https://doi.org/10.3892/or.5.3.735
Copy and paste a formatted citation
x
Spandidos Publications style
Heys S, Langlois N, Smith I, Walker L and Eremin O: NM23 gene product expression does not predict lymph node metastases or survival in young patients with colorectal cancer.. Oncol Rep 5: 735-744, 1998.
APA
Heys, S., Langlois, N., Smith, I., Walker, L., & Eremin, O. (1998). NM23 gene product expression does not predict lymph node metastases or survival in young patients with colorectal cancer.. Oncology Reports, 5, 735-744. https://doi.org/10.3892/or.5.3.735
MLA
Heys, S., Langlois, N., Smith, I., Walker, L., Eremin, O."NM23 gene product expression does not predict lymph node metastases or survival in young patients with colorectal cancer.". Oncology Reports 5.3 (1998): 735-744.
Chicago
Heys, S., Langlois, N., Smith, I., Walker, L., Eremin, O."NM23 gene product expression does not predict lymph node metastases or survival in young patients with colorectal cancer.". Oncology Reports 5, no. 3 (1998): 735-744. https://doi.org/10.3892/or.5.3.735
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