Aberrant isoform of vascular endothelial growth factor 189 expression is correlated with xenotransplantability of human esophageal cancer.

  • Authors:
    • T Tokunaga
    • H Kijima
    • Y Oshika
    • Y Fukushima
    • Y Abe
    • Y Ohnishi
    • H Yamazaki
    • T Tsuchida
    • H Makuuchi
    • N Tamaoki
    • Y Ueyama
    • M Nakamura
  • View Affiliations

  • Published online on: September 1, 1998     https://doi.org/10.3892/or.5.5.1115
  • Pages: 1115-1123
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Abstract

Xenografted neoplastic tissues are often utilized to study biology of human cancer. We studied isoform pattern (VEGF206, VEGF189, VEGF165, VEGF121) of an angiogenic factor VEGF in both esophageal primary cancers and cancer xenografts by RT-PCR analysis. Eighteen of 19 (95%) xenografts showed the cell associated aberrant isoform of VEGF189 at a significantly higher incidence than 19 of 31 (61%) primary cancers (P=0.009, Fisher's exact test). These observations suggested that the aberrant isoform of VEGF189 mRNA affects the xenotransplantability of human esophageal cancer.

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Sep-Oct 1998
Volume 5 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Tokunaga T, Kijima H, Oshika Y, Fukushima Y, Abe Y, Ohnishi Y, Yamazaki H, Tsuchida T, Makuuchi H, Tamaoki N, Tamaoki N, et al: Aberrant isoform of vascular endothelial growth factor 189 expression is correlated with xenotransplantability of human esophageal cancer.. Oncol Rep 5: 1115-1123, 1998
APA
Tokunaga, T., Kijima, H., Oshika, Y., Fukushima, Y., Abe, Y., Ohnishi, Y. ... Nakamura, M. (1998). Aberrant isoform of vascular endothelial growth factor 189 expression is correlated with xenotransplantability of human esophageal cancer.. Oncology Reports, 5, 1115-1123. https://doi.org/10.3892/or.5.5.1115
MLA
Tokunaga, T., Kijima, H., Oshika, Y., Fukushima, Y., Abe, Y., Ohnishi, Y., Yamazaki, H., Tsuchida, T., Makuuchi, H., Tamaoki, N., Ueyama, Y., Nakamura, M."Aberrant isoform of vascular endothelial growth factor 189 expression is correlated with xenotransplantability of human esophageal cancer.". Oncology Reports 5.5 (1998): 1115-1123.
Chicago
Tokunaga, T., Kijima, H., Oshika, Y., Fukushima, Y., Abe, Y., Ohnishi, Y., Yamazaki, H., Tsuchida, T., Makuuchi, H., Tamaoki, N., Ueyama, Y., Nakamura, M."Aberrant isoform of vascular endothelial growth factor 189 expression is correlated with xenotransplantability of human esophageal cancer.". Oncology Reports 5, no. 5 (1998): 1115-1123. https://doi.org/10.3892/or.5.5.1115