Alpha-fetoprotein-producing gastric cancer.

  • Authors:
    • R Lee
    • S Y Rha
    • J B Ahn
    • K Y Shim
    • J H Choi
    • H Y Lim
    • N C Yoo
    • S H Noh
    • J H Kim
    • J K Roh
    • J S Min
    • B S Kim
    • H C Chung
  • View Affiliations

  • Published online on: September 1, 1998     https://doi.org/10.3892/or.5.5.1179
  • Pages: 1179-1263
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Abstract

We measured the sero-positivity rate of serum alpha-fetoprotein (alphaFP) of gastric cancer patients by ELISA assay; forty-two curatively resected patients, 14 palliatively resected patients, 8 who received explo-laparotomy or bypass surgery and 18 patients with systemic metastasis. The sero-positive rate was 9.8% (8/82) and the positivity increased with cancer progression. Sex, age and pathological type were similar between alphaFP-positive and -negative patients. The overall synchronous hepatic metastasis rates in alphaFP-positive and alphaFP-negative groups were 37.5% (3/8) and 12.2% (9/74), respectively (p=0.08). The predictability of synchronous liver metastasis in eight alphaFP-positive patients were as follows: 37. 5% of total patients (3/8), 50.0% (3/6) of unresectable patients, and 60.0% (3/5) of patients with systemic metastasis. In three alphaFP-positive patient with liver metastasis, all the hepatic lesions were intrahepatic and multiple, while in alphaFP-negative patients, 67% (6/9) of the hepatic lesions was single intrahepatic lesion or surface nodule. The predictability of both synchronous and metachronous liver metastasis in alphaFP-positive gastric cancer patients was 75%. These findings suggested that, in advanced stomach cancer patients, especially in stage IV, alphaFP can be used in predicting liver metastasis during follow-up.

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Sep-Oct 1998
Volume 5 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Lee R, Rha S, Ahn J, Shim K, Choi J, Lim H, Yoo N, Noh S, Kim J, Roh J, Roh J, et al: Alpha-fetoprotein-producing gastric cancer.. Oncol Rep 5: 1179-1263, 1998
APA
Lee, R., Rha, S., Ahn, J., Shim, K., Choi, J., Lim, H. ... Chung, H. (1998). Alpha-fetoprotein-producing gastric cancer.. Oncology Reports, 5, 1179-1263. https://doi.org/10.3892/or.5.5.1179
MLA
Lee, R., Rha, S., Ahn, J., Shim, K., Choi, J., Lim, H., Yoo, N., Noh, S., Kim, J., Roh, J., Min, J., Kim, B., Chung, H."Alpha-fetoprotein-producing gastric cancer.". Oncology Reports 5.5 (1998): 1179-1263.
Chicago
Lee, R., Rha, S., Ahn, J., Shim, K., Choi, J., Lim, H., Yoo, N., Noh, S., Kim, J., Roh, J., Min, J., Kim, B., Chung, H."Alpha-fetoprotein-producing gastric cancer.". Oncology Reports 5, no. 5 (1998): 1179-1263. https://doi.org/10.3892/or.5.5.1179