No susceptibility of colon tissue implanted into the glandular stomach of rats to N-nitroso-N-methylurea carcinogenesis.

Ando,Y; Uesaka,T; Kido,S; Fujimoto,N; Tatematsu,M; Ishimura,Y; Shiraki,K; Hirata,S; Kuramoto,K; Shoji,S; Katoh,O; Watanabe,H

doi:10.3892/or.5.6.1373

No susceptibility of colon tissue implanted into the glandular stomach of rats to N-nitroso-N-methylurea carcinogenesis.

Authors:
- Y Ando
- T Uesaka
- S Kido
- N Fujimoto
- M Tatematsu
- Y Ishimura
- K Shiraki
- S Hirata
- K Kuramoto
- S Shoji
- O Katoh
- H Watanabe
View Affiliations

Affiliations: Department of Environment and Mutation, Hiroshima University, Minami-ku, Hiroshima 734-8553, Japan.
Published online on: November 1, 1998 https://doi.org/10.3892/or.5.6.1373
Pages: 1373-1379

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The present study was undertaken to determine the response of colonic mucosa implanted into the stomach fundus in 6-week-old male F344 rats to oral administration of N-nitroso-N-methylurea (MNU). In graft + MNU, 15% animals had tumors in the implanted colon tissue whereas a 26% incidence of gastric tumors was observed for the pyloric mucosa. In MNU alone, 30% of rats demonstrated gastric tumors. In graft alone 10% of tumors were observed in the grafted site but none in the pylorus. Thus while graft tissue may intrinsically have an elevated risk of tumor development, no susceptibility to MNU was observed in the present study.