The prevalence of p53 immunoreactivity in anal canal carcinoma.

  • Authors:
    • M Indinnimeo
    • C Cicchini
    • A Stazi
    • M R Limiti
    • E Giarnieri
    • C Ghini
    • A Vecchione
  • View Affiliations

  • Published online on: November 1, 1998     https://doi.org/10.3892/or.5.6.1455
  • Pages: 1455-1462
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Abstract

We examined the relationship between p53 expression and clinicopathologic parameters in anal carcinoma. p53 immunoreactivity was detected in 14/18 (77.7%) tumors. Significant association was found between p53 expression and depth of invasion. There was no significant association between p53 expression and histologic type, lymph node metastasis, age and prognosis. Possibly the genetic pathway to anal carcinoma involving p53 gene overexpression confer aggressive growth pattern, but it does not result in worse prognosis. The absence of correlation between p53 overexpression and prognosis could be explained by tumors negative for mutations having an excess of wild-type p53 protein.

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Nov-Dec 1998
Volume 5 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Indinnimeo M, Cicchini C, Stazi A, Limiti M, Giarnieri E, Ghini C and Vecchione A: The prevalence of p53 immunoreactivity in anal canal carcinoma.. Oncol Rep 5: 1455-1462, 1998
APA
Indinnimeo, M., Cicchini, C., Stazi, A., Limiti, M., Giarnieri, E., Ghini, C., & Vecchione, A. (1998). The prevalence of p53 immunoreactivity in anal canal carcinoma.. Oncology Reports, 5, 1455-1462. https://doi.org/10.3892/or.5.6.1455
MLA
Indinnimeo, M., Cicchini, C., Stazi, A., Limiti, M., Giarnieri, E., Ghini, C., Vecchione, A."The prevalence of p53 immunoreactivity in anal canal carcinoma.". Oncology Reports 5.6 (1998): 1455-1462.
Chicago
Indinnimeo, M., Cicchini, C., Stazi, A., Limiti, M., Giarnieri, E., Ghini, C., Vecchione, A."The prevalence of p53 immunoreactivity in anal canal carcinoma.". Oncology Reports 5, no. 6 (1998): 1455-1462. https://doi.org/10.3892/or.5.6.1455