Expression of proliferating cell nuclear antigen in follicular thyroid tumors: correlation with clinicopathological findings.

  • Authors:
    • V Vassko
    • S Garcia
    • J F Henry
    • C De Micco
  • View Affiliations

  • Published online on: March 1, 1999     https://doi.org/10.3892/or.6.2.359
  • Pages: 359-423
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The purpose of this study was to correlate proliferating cell nuclear antigen (PCNA) immunostaining with clinicopathological findings in 60 follicular thyroid tumors. Mean proliferative index (PI) was significantly higher for carcinoma (73%) than microfollicular adenoma (19.6%) (p<0.0001). For atypical and oncocytic adenomas, intermediate PI values (64% and 50%) correlated with size and cytological atypia but not with sex and age. PCNA immunostaining is of limited value for differential diagnosis of malignant and atypical tumors but could be useful for identification of actively growing atypical follicular thyroid nodules on fine needle aspiration biopsies.

Related Articles

Journal Cover

Mar-Apr 1999
Volume 6 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Vassko V, Garcia S, Henry J and De Micco C: Expression of proliferating cell nuclear antigen in follicular thyroid tumors: correlation with clinicopathological findings.. Oncol Rep 6: 359-423, 1999.
APA
Vassko, V., Garcia, S., Henry, J., & De Micco, C. (1999). Expression of proliferating cell nuclear antigen in follicular thyroid tumors: correlation with clinicopathological findings.. Oncology Reports, 6, 359-423. https://doi.org/10.3892/or.6.2.359
MLA
Vassko, V., Garcia, S., Henry, J., De Micco, C."Expression of proliferating cell nuclear antigen in follicular thyroid tumors: correlation with clinicopathological findings.". Oncology Reports 6.2 (1999): 359-423.
Chicago
Vassko, V., Garcia, S., Henry, J., De Micco, C."Expression of proliferating cell nuclear antigen in follicular thyroid tumors: correlation with clinicopathological findings.". Oncology Reports 6, no. 2 (1999): 359-423. https://doi.org/10.3892/or.6.2.359