Structure and expression of variant BRCA2a lacking the transactivation domain.

  • Authors:
    • J P Zou
    • Y Hirose
    • H Siddique
    • V N Rao
    • E S Reddy
  • View Affiliations

  • Published online on: Monday, March 1, 1999
  • Pages: 437-477 DOI: 10.3892/or.6.2.437

Abstract

BRCA1 and BRCA2 are tumor suppressor genes shown to be involved in 90% of familial breast cancers and also known to be involved in ovarian and prostate cancers. Both BRCA1 and BRCA2 gene products are regulated in a cell cycle-dependent manner and have potential transactivation function. Here, we show that BRCA2 undergoes differential splicing giving rise to a novel variant protein BRCA2a, lacking putative transcriptional activation domain. Both BRCA2a and BRCA2 are expressed at high levels in thymus and testis but moderate levels in mammary gland and prostate suggesting that BRCA2a and BRCA2 may have a role in the development and differentiation of these tissues.

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March 1999
Volume 6 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

2015 Impact Factor: 2.486
Ranked #31/211 Oncology
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APA
Zou, J., Hirose, Y., Siddique, H., Rao, V., & Reddy, E. (1999). Structure and expression of variant BRCA2a lacking the transactivation domain.. Oncology Reports, 6, 437-477. http://dx.doi.org/10.3892/or.6.2.437
MLA
Zou, J., Hirose, Y., Siddique, H., Rao, V., Reddy, E."Structure and expression of variant BRCA2a lacking the transactivation domain.". Oncology Reports 6.2 (1999): 437-477.
Chicago
Zou, J., Hirose, Y., Siddique, H., Rao, V., Reddy, E."Structure and expression of variant BRCA2a lacking the transactivation domain.". Oncology Reports 6, no. 2 (1999): 437-477. http://dx.doi.org/10.3892/or.6.2.437