Pre-operative IL-2 immunoprophylaxis of cancer recurrence: long-term clinical results of a phase II study in radically operable colorectal cancer.

  • Authors:
    • F Brivio
    • P Lissoni
    • L Fumagalli
    • M Girlando
    • M T Marsili
    • A Nespoli
    • F Uggeri
  • View Affiliations

  • Published online on: November 1, 1999     https://doi.org/10.3892/or.6.6.1205
  • Pages: 1205-1212
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Abstract

This study evaluates retrospectively the outcome of 20 colorectal cancer patients radically operated (M/F 13/7; primary/recurrent 15/5; Dukes B=11; C=6; D=3) who received pre-operative IL-2 (18,000, 000 IU/daily s.c. for 3 days) and the outcome of 40 colorectal cancer (primary/recurrent 40/0) patients age, sex and stage-matched radically operated, as control group. After a median follow-up of 72 months, in the IL-2 pre-operative group we observed 6/20 recurrences (30%) vs. 19/40 (47.5%) in controls. Mean and median disease-free period in patients who relapsed were respectively 21 months and 20.5 months (range 6-36) in IL-2 group vs. 14.1 and 12 months in the control group (range 3-34). After a 5-year follow-up, 4/20 (20%) IL-2 treated patients were dead vs. 19/40 control patients (47.5%) (log-rank chi2=3.7, p=0.05). Pre-operative IL-2 administration is safe, active in preventing post-operative lymphocytopenia and seems to improve the clinical outcome in radically operated colorectal cancer patients.

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Nov-Dec 1999
Volume 6 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Brivio F, Lissoni P, Fumagalli L, Girlando M, Marsili M, Nespoli A and Uggeri F: Pre-operative IL-2 immunoprophylaxis of cancer recurrence: long-term clinical results of a phase II study in radically operable colorectal cancer.. Oncol Rep 6: 1205-1212, 1999
APA
Brivio, F., Lissoni, P., Fumagalli, L., Girlando, M., Marsili, M., Nespoli, A., & Uggeri, F. (1999). Pre-operative IL-2 immunoprophylaxis of cancer recurrence: long-term clinical results of a phase II study in radically operable colorectal cancer.. Oncology Reports, 6, 1205-1212. https://doi.org/10.3892/or.6.6.1205
MLA
Brivio, F., Lissoni, P., Fumagalli, L., Girlando, M., Marsili, M., Nespoli, A., Uggeri, F."Pre-operative IL-2 immunoprophylaxis of cancer recurrence: long-term clinical results of a phase II study in radically operable colorectal cancer.". Oncology Reports 6.6 (1999): 1205-1212.
Chicago
Brivio, F., Lissoni, P., Fumagalli, L., Girlando, M., Marsili, M., Nespoli, A., Uggeri, F."Pre-operative IL-2 immunoprophylaxis of cancer recurrence: long-term clinical results of a phase II study in radically operable colorectal cancer.". Oncology Reports 6, no. 6 (1999): 1205-1212. https://doi.org/10.3892/or.6.6.1205