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A phase III randomized study comparing doxifluridine and 5-fluorouracil as supportive chemotherapy in advanced and recurrent gastric cancer.

  • Authors:
    • K Kondo
    • J Sakamoto
    • H Nakazato
    • A Koike
    • T Kitoh
    • K Hachisuka
    • S Saji
    • J Yura
    • Y Nimura
    • N Hamajima
    • K Katoh
    • A Yamaguchi
    • K I Miya
    • M Yamauchi
    • I Mizuno
    • M Nagino
    • H Takagi

  • View Affiliations

  • Published online on: May 1, 2000     https://doi.org/10.3892/or.7.3.485
  • Pages: 485-575
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Abstract

We conducted a phase III randomized study to investigate effects of supportive chemotherapy with oral doxifluridine (group A, 75 patients) or 5-fluorouracil (group B, 75 patients) in advanced gastric cancer when intensive chemotherapy was not an option. Although there were no significant differences between the groups with regard to survival, hospital-free survival and time to progression, median values of 3 endpoints were superior in group A. Secondary analysis showed that group A patients with prior chemotherapy tended to have longer survival and hospital-free survival and significantly longer time to progression.

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May-Jun 2000
Volume 7 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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  • Journal Metrics
  • Impact Factor: 4.2
  • Ranked Oncology
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  • CiteScore: 8.4
  • CiteScore Rank: Q1: #68/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.786
  • SCImago Journal Rank (SJR): 0.812
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Spandidos Publications style
Kondo K, Sakamoto J, Nakazato H, Koike A, Kitoh T, Hachisuka K, Saji S, Yura J, Nimura Y, Hamajima N, Hamajima N, et al: A phase III randomized study comparing doxifluridine and 5-fluorouracil as supportive chemotherapy in advanced and recurrent gastric cancer.. Oncol Rep 7: 485-575, 2000
APA
Kondo, K., Sakamoto, J., Nakazato, H., Koike, A., Kitoh, T., Hachisuka, K. ... Takagi, H. (2000). A phase III randomized study comparing doxifluridine and 5-fluorouracil as supportive chemotherapy in advanced and recurrent gastric cancer.. Oncology Reports, 7, 485-575. https://doi.org/10.3892/or.7.3.485
MLA
Kondo, K., Sakamoto, J., Nakazato, H., Koike, A., Kitoh, T., Hachisuka, K., Saji, S., Yura, J., Nimura, Y., Hamajima, N., Katoh, K., Yamaguchi, A., Miya, K., Yamauchi, M., Mizuno, I., Nagino, M., Takagi, H."A phase III randomized study comparing doxifluridine and 5-fluorouracil as supportive chemotherapy in advanced and recurrent gastric cancer.". Oncology Reports 7.3 (2000): 485-575.
Chicago
Kondo, K., Sakamoto, J., Nakazato, H., Koike, A., Kitoh, T., Hachisuka, K., Saji, S., Yura, J., Nimura, Y., Hamajima, N., Katoh, K., Yamaguchi, A., Miya, K., Yamauchi, M., Mizuno, I., Nagino, M., Takagi, H."A phase III randomized study comparing doxifluridine and 5-fluorouracil as supportive chemotherapy in advanced and recurrent gastric cancer.". Oncology Reports 7, no. 3 (2000): 485-575. https://doi.org/10.3892/or.7.3.485