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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May-Jun 2000 Volume 7 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

A multivariate analysis for predicting cisplatin-induced delayed emesis.

  • Authors:
    • X Pivot
    • N Marghali
    • M C Etienne
    • R J Bensadoun
    • A Thyss
    • J Otto
    • E François
    • N Renée
    • J L Lagrange
    • M Schneider
    • G Milano

  • View Affiliations / Copyright

    Affiliations: Centre Antoine Lacassagne, Oncopharmacology Unit, 06189 Nice, France.
  • Pages: 515-524
    |
    Published online on: May 1, 2000
       https://doi.org/10.3892/or.7.3.515
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Abstract

The present study was designed to address the question of the early identification of patients at risk of developing cisplatin (CP)-related delayed emesis. This study included demographic, clinical, biological and pharmacological data and was conducted on 110 consecutive patients treated by CP-based chemotherapy. A previously validated single-point CP pharmacokinetic evaluation was performed in all patients. A total of 110 cycles was analyzed. Delayed vomiting (i.e., occurring between day 3 and day 7 following CP administration) was observed in 36.4% of cycles. Among the tested variables, the occurrence of delayed emesis was significantly related to elevated ultrafilterable (UF) platinum concentration (measured 16 h after the end of CP administration) and to low plasma magnesium concentration (measured 48 h before CP administration). Risk-thresholds for delayed emesis were established for UF platinum and magnesemia, at 60 ng/ml and 58 mmol/l, respectively. In the sub-group of patients with magnesemia determination, this later parameter was the only significant predictor of delayed emesis. Gender, cycle number, primary cancer location and age were not associated with the risk of developing delayed emesis. The ability to select patients at risk of delayed vomiting may offer a practical means of targeting administration of specific treatments.

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Copy and paste a formatted citation
Spandidos Publications style
Pivot X, Marghali N, Etienne M, Bensadoun R, Thyss A, Otto J, François E, Renée N, Lagrange J, Schneider M, Schneider M, et al: A multivariate analysis for predicting cisplatin-induced delayed emesis.. Oncol Rep 7: 515-524, 2000.
APA
Pivot, X., Marghali, N., Etienne, M., Bensadoun, R., Thyss, A., Otto, J. ... Milano, G. (2000). A multivariate analysis for predicting cisplatin-induced delayed emesis.. Oncology Reports, 7, 515-524. https://doi.org/10.3892/or.7.3.515
MLA
Pivot, X., Marghali, N., Etienne, M., Bensadoun, R., Thyss, A., Otto, J., François, E., Renée, N., Lagrange, J., Schneider, M., Milano, G."A multivariate analysis for predicting cisplatin-induced delayed emesis.". Oncology Reports 7.3 (2000): 515-524.
Chicago
Pivot, X., Marghali, N., Etienne, M., Bensadoun, R., Thyss, A., Otto, J., François, E., Renée, N., Lagrange, J., Schneider, M., Milano, G."A multivariate analysis for predicting cisplatin-induced delayed emesis.". Oncology Reports 7, no. 3 (2000): 515-524. https://doi.org/10.3892/or.7.3.515
Copy and paste a formatted citation
x
Spandidos Publications style
Pivot X, Marghali N, Etienne M, Bensadoun R, Thyss A, Otto J, François E, Renée N, Lagrange J, Schneider M, Schneider M, et al: A multivariate analysis for predicting cisplatin-induced delayed emesis.. Oncol Rep 7: 515-524, 2000.
APA
Pivot, X., Marghali, N., Etienne, M., Bensadoun, R., Thyss, A., Otto, J. ... Milano, G. (2000). A multivariate analysis for predicting cisplatin-induced delayed emesis.. Oncology Reports, 7, 515-524. https://doi.org/10.3892/or.7.3.515
MLA
Pivot, X., Marghali, N., Etienne, M., Bensadoun, R., Thyss, A., Otto, J., François, E., Renée, N., Lagrange, J., Schneider, M., Milano, G."A multivariate analysis for predicting cisplatin-induced delayed emesis.". Oncology Reports 7.3 (2000): 515-524.
Chicago
Pivot, X., Marghali, N., Etienne, M., Bensadoun, R., Thyss, A., Otto, J., François, E., Renée, N., Lagrange, J., Schneider, M., Milano, G."A multivariate analysis for predicting cisplatin-induced delayed emesis.". Oncology Reports 7, no. 3 (2000): 515-524. https://doi.org/10.3892/or.7.3.515
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