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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May-Jun 2000 Volume 7 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Histological and molecular mapping of adenocarcinoma of the oesophagus and gastroesophageal junction: loss of heterozygosity occurs in histologically normal epithelium in the oesophagus and stomach.

  • Authors:
    • K Dolan
    • J Garde
    • S J Walker
    • R Sutton
    • J Gosney
    • J K Field
  • View Affiliations / Copyright

    Affiliations: Molecular Genetics and Oncology Group, Department of Clinical Dental Sciences, Liverpool L69 3BX, UK.
  • Pages: 521-529
    |
    Published online on: May 1, 2000
       https://doi.org/10.3892/or.7.3.521
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Abstract

Seventy malignant, premalignant and histologically normal biopsies from 7 oesophagogastrectomy specimens of adenocarcinomas of the lower oesophagus and gastroesophageal junction were analysed for loss of heterozygosity (LOH) at 9 known or putative gene loci. LOH was detected in 20 of 27 (74%) malignant biopsies, 4 of 7 (57%) biopsies of dysplasia, 2 of 12 (25%) biopsies of histologically normal oesophagus adjacent to adenocarcinoma, and in 2 of 14 (14%) biopsies of histologically normal stomach adjacent to adenocarcinoma. LOH at the VHL, APC, CDKN2 and DCC tumour suppressor and MSH3 mismatch repair gene loci can be detected in histologically normal tissue and in adjacent adenocarcinoma, and are potential markers of early neoplastic progression.

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Copy and paste a formatted citation
Spandidos Publications style
Dolan K, Garde J, Walker S, Sutton R, Gosney J and Field J: Histological and molecular mapping of adenocarcinoma of the oesophagus and gastroesophageal junction: loss of heterozygosity occurs in histologically normal epithelium in the oesophagus and stomach.. Oncol Rep 7: 521-529, 2000.
APA
Dolan, K., Garde, J., Walker, S., Sutton, R., Gosney, J., & Field, J. (2000). Histological and molecular mapping of adenocarcinoma of the oesophagus and gastroesophageal junction: loss of heterozygosity occurs in histologically normal epithelium in the oesophagus and stomach.. Oncology Reports, 7, 521-529. https://doi.org/10.3892/or.7.3.521
MLA
Dolan, K., Garde, J., Walker, S., Sutton, R., Gosney, J., Field, J."Histological and molecular mapping of adenocarcinoma of the oesophagus and gastroesophageal junction: loss of heterozygosity occurs in histologically normal epithelium in the oesophagus and stomach.". Oncology Reports 7.3 (2000): 521-529.
Chicago
Dolan, K., Garde, J., Walker, S., Sutton, R., Gosney, J., Field, J."Histological and molecular mapping of adenocarcinoma of the oesophagus and gastroesophageal junction: loss of heterozygosity occurs in histologically normal epithelium in the oesophagus and stomach.". Oncology Reports 7, no. 3 (2000): 521-529. https://doi.org/10.3892/or.7.3.521
Copy and paste a formatted citation
x
Spandidos Publications style
Dolan K, Garde J, Walker S, Sutton R, Gosney J and Field J: Histological and molecular mapping of adenocarcinoma of the oesophagus and gastroesophageal junction: loss of heterozygosity occurs in histologically normal epithelium in the oesophagus and stomach.. Oncol Rep 7: 521-529, 2000.
APA
Dolan, K., Garde, J., Walker, S., Sutton, R., Gosney, J., & Field, J. (2000). Histological and molecular mapping of adenocarcinoma of the oesophagus and gastroesophageal junction: loss of heterozygosity occurs in histologically normal epithelium in the oesophagus and stomach.. Oncology Reports, 7, 521-529. https://doi.org/10.3892/or.7.3.521
MLA
Dolan, K., Garde, J., Walker, S., Sutton, R., Gosney, J., Field, J."Histological and molecular mapping of adenocarcinoma of the oesophagus and gastroesophageal junction: loss of heterozygosity occurs in histologically normal epithelium in the oesophagus and stomach.". Oncology Reports 7.3 (2000): 521-529.
Chicago
Dolan, K., Garde, J., Walker, S., Sutton, R., Gosney, J., Field, J."Histological and molecular mapping of adenocarcinoma of the oesophagus and gastroesophageal junction: loss of heterozygosity occurs in histologically normal epithelium in the oesophagus and stomach.". Oncology Reports 7, no. 3 (2000): 521-529. https://doi.org/10.3892/or.7.3.521
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