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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May-Jun 2000 Volume 7 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

A conditioned medium from a human liposarcoma-derived cell line induces p53-dependent apoptosis in several tumor cell lines.

  • Authors:
    • A Mancini
    • A Borrelli
    • M T Masucci
    • A Schiattarella
    • S Filice
    • J Rashan
    • T Maggino

  • View Affiliations / Copyright

    Affiliations: National Cancer Institute, Fondazione Pascale, 80110 Naples, Italy.
  • Pages: 629-666
    |
    Published online on: May 1, 2000
       https://doi.org/10.3892/or.7.3.629
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Abstract

A novel cell line, named LSA, has been obtained, stabilized, and characterized from a human liposarcoma. These cells have morphological and biochemical features strongly resembling the adipocytes and were able to grow in the Ham's F12 medium, in presence or absence of FCS. A conditioned medium (LSA-CM) was obtained by growing the LSA cells in the F12 medium in the absence of FCS. LSA-CM had cytostatic and cytotoxic effects (apoptosis and necrosis) associated with down-regulation of c-myc and upregulation of p53 in several human cell lines (breast, lung, glioblastoma, etc. ). The MCF-7 and glioblastoma cells were killed by LSA-CM in 5-6 days, whereas the same cells were killed by LSA-CM co-incubated with low doses of cisplatin in 30 h. LSA-CM peri-tumoral injections for 15 days in Balb-c-fc3H mice affected by mammary tumors, resulted in the rapid disruption of tumors and absence of metastases. In contrast, in the untreated animals the tumor masses were 4 times larger than initial lesions, and numerous metastases were found in the lungs. The toxicity analysis of LSA-CM, performed on three different animal species, showed that LSA-CM is absolutely free of acute, subacute, and subchronic toxicity. The possible use of LSA-CM/cisplatin for cancer treatment is discussed.

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Copy and paste a formatted citation
Spandidos Publications style
Mancini A, Borrelli A, Masucci M, Schiattarella A, Filice S, Rashan J and Maggino T: A conditioned medium from a human liposarcoma-derived cell line induces p53-dependent apoptosis in several tumor cell lines.. Oncol Rep 7: 629-666, 2000.
APA
Mancini, A., Borrelli, A., Masucci, M., Schiattarella, A., Filice, S., Rashan, J., & Maggino, T. (2000). A conditioned medium from a human liposarcoma-derived cell line induces p53-dependent apoptosis in several tumor cell lines.. Oncology Reports, 7, 629-666. https://doi.org/10.3892/or.7.3.629
MLA
Mancini, A., Borrelli, A., Masucci, M., Schiattarella, A., Filice, S., Rashan, J., Maggino, T."A conditioned medium from a human liposarcoma-derived cell line induces p53-dependent apoptosis in several tumor cell lines.". Oncology Reports 7.3 (2000): 629-666.
Chicago
Mancini, A., Borrelli, A., Masucci, M., Schiattarella, A., Filice, S., Rashan, J., Maggino, T."A conditioned medium from a human liposarcoma-derived cell line induces p53-dependent apoptosis in several tumor cell lines.". Oncology Reports 7, no. 3 (2000): 629-666. https://doi.org/10.3892/or.7.3.629
Copy and paste a formatted citation
x
Spandidos Publications style
Mancini A, Borrelli A, Masucci M, Schiattarella A, Filice S, Rashan J and Maggino T: A conditioned medium from a human liposarcoma-derived cell line induces p53-dependent apoptosis in several tumor cell lines.. Oncol Rep 7: 629-666, 2000.
APA
Mancini, A., Borrelli, A., Masucci, M., Schiattarella, A., Filice, S., Rashan, J., & Maggino, T. (2000). A conditioned medium from a human liposarcoma-derived cell line induces p53-dependent apoptosis in several tumor cell lines.. Oncology Reports, 7, 629-666. https://doi.org/10.3892/or.7.3.629
MLA
Mancini, A., Borrelli, A., Masucci, M., Schiattarella, A., Filice, S., Rashan, J., Maggino, T."A conditioned medium from a human liposarcoma-derived cell line induces p53-dependent apoptosis in several tumor cell lines.". Oncology Reports 7.3 (2000): 629-666.
Chicago
Mancini, A., Borrelli, A., Masucci, M., Schiattarella, A., Filice, S., Rashan, J., Maggino, T."A conditioned medium from a human liposarcoma-derived cell line induces p53-dependent apoptosis in several tumor cell lines.". Oncology Reports 7, no. 3 (2000): 629-666. https://doi.org/10.3892/or.7.3.629
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