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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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May-Jun 2000 Volume 7 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Serum anti-p53 antibodies in patients with lung cancer.

  • Authors:
    • U Mack
    • D Ukena
    • M Montenarh
    • G W Sybrecht

  • View Affiliations / Copyright

    Affiliations: Innere Medizin V, Building 91, Universitat des Saarlandes, D-66421 Homburg/Saar, Germany.
  • Pages: 669-743
    |
    Published online on: May 1, 2000
       https://doi.org/10.3892/or.7.3.669
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Abstract

Antibodies against the p53 protein are produced by some cancer patients. In some tumour entities, the presence of p53 autoantibodies have been linked to poorer survival. This study was designed to assess the prevalence and prognostic implications of p53 autoantibodies in patients with lung cancer. Serum samples of 180 patients were tested for antibodies against p53 protein using an ELISA. We studied 134 patients with primary lung cancer [histology: small cell lung carcinoma (SCLC) n=35; non-small cell lung carcinoma (NSCLC) n=99]. The control group consisted of 46 patients without lung cancer. In 17/134 (12.6%) of the cancer patients, p53 autoantibodies were detected (4/35 SCLC, 13/99 NSCLC). Most of the positive results were found in advanced stages of NSCLC (stage I-IIIA: 1/34; stage IIIB/IV: 12/65). One of the 46 control patients tested positive. Statistical analysis of survival shows no correlation with p53 antibody status in SCLC, but a significant correlation with shorter survival in NSCLC (p=0.01). After correction for stage of disease this correlation remains significant (stage IIIB/IV: p=0.02). In our series, the presence of anti-p53 autoantibodies is almost exclusively linked to the presence of malignant disease. Prognosis for patients with NSCLC, but not SCLC seems to be linked to the p53 autoantibody status.

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Copy and paste a formatted citation
Spandidos Publications style
Mack U, Ukena D, Montenarh M and Sybrecht G: Serum anti-p53 antibodies in patients with lung cancer.. Oncol Rep 7: 669-743, 2000.
APA
Mack, U., Ukena, D., Montenarh, M., & Sybrecht, G. (2000). Serum anti-p53 antibodies in patients with lung cancer.. Oncology Reports, 7, 669-743. https://doi.org/10.3892/or.7.3.669
MLA
Mack, U., Ukena, D., Montenarh, M., Sybrecht, G."Serum anti-p53 antibodies in patients with lung cancer.". Oncology Reports 7.3 (2000): 669-743.
Chicago
Mack, U., Ukena, D., Montenarh, M., Sybrecht, G."Serum anti-p53 antibodies in patients with lung cancer.". Oncology Reports 7, no. 3 (2000): 669-743. https://doi.org/10.3892/or.7.3.669
Copy and paste a formatted citation
x
Spandidos Publications style
Mack U, Ukena D, Montenarh M and Sybrecht G: Serum anti-p53 antibodies in patients with lung cancer.. Oncol Rep 7: 669-743, 2000.
APA
Mack, U., Ukena, D., Montenarh, M., & Sybrecht, G. (2000). Serum anti-p53 antibodies in patients with lung cancer.. Oncology Reports, 7, 669-743. https://doi.org/10.3892/or.7.3.669
MLA
Mack, U., Ukena, D., Montenarh, M., Sybrecht, G."Serum anti-p53 antibodies in patients with lung cancer.". Oncology Reports 7.3 (2000): 669-743.
Chicago
Mack, U., Ukena, D., Montenarh, M., Sybrecht, G."Serum anti-p53 antibodies in patients with lung cancer.". Oncology Reports 7, no. 3 (2000): 669-743. https://doi.org/10.3892/or.7.3.669
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