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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Sep-Oct 2000 Volume 7 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Sep-Oct 2000 Volume 7 Issue 5

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Article

Evidence for in the appearance of mRNAs of nucleotide excision repair genes, in human ovarian cancer tissues.

  • Authors:
    • E Reed
    • M Dabholkar
    • K Thornton
    • C Thompson
    • J J Yu
    • F Bostick-Bruton

  • View Affiliations / Copyright

    Affiliations: Medical Ovarian Cancer Section, Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. reed92@helix.nih.gov
  • Pages: 1123-1131
    |
    Published online on: September 1, 2000
       https://doi.org/10.3892/or.7.5.1123
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Abstract

Nucleotide excision repair (NER) is the DNA repair pathway through which cisplatin-DNA intrastrand adduct is repaired. Clinical studies have shown that increased mRNA expression of selected genes involved in the rate-limiting step of NER, appear to be closely associated with clinical resistance to platinum agents. These specific studies have led to the possibility of an assessment of the order in which, the appearance of mRNAs of selected NER genes may occur. Included in this assessment are ERCC1, XPB, CSB, and XPA, studied in 28 ovarian cancer tumor tissue specimens. The study of these four genes, in pairs, from 28 ovarian cancer specimens, results in 168 separate observations. Based on the mRNA expression patterns of these genes in these tissues, it is suggested that ERCC1 mRNA may appear before the mRNA of any of the other genes, in an obligate fashion. This is followed by XPB mRNA; which appears before the mRNA of XPA; which in turn, may appear before CSB. This pattern is consistent with what we have reported previously, in non-malignant human bone marrow specimens from a cohort of 52 patients.

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Copy and paste a formatted citation
Spandidos Publications style
Reed E, Dabholkar M, Thornton K, Thompson C, Yu J and Bostick-Bruton F: Evidence for in the appearance of mRNAs of nucleotide excision repair genes, in human ovarian cancer tissues.. Oncol Rep 7: 1123-1131, 2000.
APA
Reed, E., Dabholkar, M., Thornton, K., Thompson, C., Yu, J., & Bostick-Bruton, F. (2000). Evidence for in the appearance of mRNAs of nucleotide excision repair genes, in human ovarian cancer tissues.. Oncology Reports, 7, 1123-1131. https://doi.org/10.3892/or.7.5.1123
MLA
Reed, E., Dabholkar, M., Thornton, K., Thompson, C., Yu, J., Bostick-Bruton, F."Evidence for in the appearance of mRNAs of nucleotide excision repair genes, in human ovarian cancer tissues.". Oncology Reports 7.5 (2000): 1123-1131.
Chicago
Reed, E., Dabholkar, M., Thornton, K., Thompson, C., Yu, J., Bostick-Bruton, F."Evidence for in the appearance of mRNAs of nucleotide excision repair genes, in human ovarian cancer tissues.". Oncology Reports 7, no. 5 (2000): 1123-1131. https://doi.org/10.3892/or.7.5.1123
Copy and paste a formatted citation
x
Spandidos Publications style
Reed E, Dabholkar M, Thornton K, Thompson C, Yu J and Bostick-Bruton F: Evidence for in the appearance of mRNAs of nucleotide excision repair genes, in human ovarian cancer tissues.. Oncol Rep 7: 1123-1131, 2000.
APA
Reed, E., Dabholkar, M., Thornton, K., Thompson, C., Yu, J., & Bostick-Bruton, F. (2000). Evidence for in the appearance of mRNAs of nucleotide excision repair genes, in human ovarian cancer tissues.. Oncology Reports, 7, 1123-1131. https://doi.org/10.3892/or.7.5.1123
MLA
Reed, E., Dabholkar, M., Thornton, K., Thompson, C., Yu, J., Bostick-Bruton, F."Evidence for in the appearance of mRNAs of nucleotide excision repair genes, in human ovarian cancer tissues.". Oncology Reports 7.5 (2000): 1123-1131.
Chicago
Reed, E., Dabholkar, M., Thornton, K., Thompson, C., Yu, J., Bostick-Bruton, F."Evidence for in the appearance of mRNAs of nucleotide excision repair genes, in human ovarian cancer tissues.". Oncology Reports 7, no. 5 (2000): 1123-1131. https://doi.org/10.3892/or.7.5.1123
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