Survival of patients with cutaneous T-cell lymphoma after treatment with extracorporeal photochemotherapy.

  • Authors:
    • U Wollina
    • K Liebold
    • M Kaatz
    • A Looks
    • A Stuhlert
    • D Lange
  • View Affiliations

  • Published online on: November 1, 2000     https://doi.org/10.3892/or.7.6.1197
  • Pages: 1197-1398
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Abstract

Few studies have assessed the long-term outcome of patients with cutaneous T-cell lymphoma (CTCL) treated with extracorporeal photochemotherapy (ECP). Our objective was to assess the efficacy, safety, and survival of a cohort of patients with refractory CTCL in stages Ib to III who were treated with ECP. A retrospective study was performed. Twenty patients (19 male, 1 female) aged 38 to 87 years with CTCL of the mycosis fungoides type (n=17) and primary cutaneous Ki-1 lymphoma (n=2) were treated twice a month. Sixteen had an adjunctive treatment with interferon alpha (IFN alpha) s.c. 3 times a week in the maximal tolerable dosage (i.e. up to 21x106). A complete response was achieved in 10 patients, a partial response in three and a stable disease in seven patients (response rate 65.0%). The overall survival was 29.4+/-16.0 months, the event-free survival was 26.2+/-12.4 months, and the progression-free survival was 23. 4+/-12.2 months. Four patients died of causes unrelated to CTCL and two patient died of CTCL. Median survival time was 26 months. No severe side effects were noted. ECP is a safe alternative therapy for CTCL. In particular when combined with IFN alpha it can induce long-term remissions.

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Nov-Dec 2000
Volume 7 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wollina U, Liebold K, Kaatz M, Looks A, Stuhlert A and Lange D: Survival of patients with cutaneous T-cell lymphoma after treatment with extracorporeal photochemotherapy.. Oncol Rep 7: 1197-1398, 2000.
APA
Wollina, U., Liebold, K., Kaatz, M., Looks, A., Stuhlert, A., & Lange, D. (2000). Survival of patients with cutaneous T-cell lymphoma after treatment with extracorporeal photochemotherapy.. Oncology Reports, 7, 1197-1398. https://doi.org/10.3892/or.7.6.1197
MLA
Wollina, U., Liebold, K., Kaatz, M., Looks, A., Stuhlert, A., Lange, D."Survival of patients with cutaneous T-cell lymphoma after treatment with extracorporeal photochemotherapy.". Oncology Reports 7.6 (2000): 1197-1398.
Chicago
Wollina, U., Liebold, K., Kaatz, M., Looks, A., Stuhlert, A., Lange, D."Survival of patients with cutaneous T-cell lymphoma after treatment with extracorporeal photochemotherapy.". Oncology Reports 7, no. 6 (2000): 1197-1398. https://doi.org/10.3892/or.7.6.1197