Cyclooxygenase-2 immunoreactivity in depressed-type colorectal adenomas and cancers.

  • Authors:
    • K Saito
    • K Arai
    • M Mori
  • View Affiliations

  • Published online on: November 1, 2000     https://doi.org/10.3892/or.7.6.1217
  • Pages: 1217-1226
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Abstract

In order to clarify the relationship of the cyclooxygenase-2 immunoreactivity and the progression of depressed-type colorectal adenomas and cancers, we examined cyclooxygenase-2 expression in depressed-type colorectal adenomas and cancers. Immunohistochemical staining was performed by the streptavidin-biotin method. Among 100 adenomas, depressed-type were found in 15, cyclooxygenase-2 expression was not detected in depressed-types, and lesion size in depressed-types did not differ from that in others. Among 100 submucosal invasive cancers, depressed-type were found in 14, cyclooxygenase-2 expression was not detected in depressed-types, and lesion size in tumor with depressed-type did not differ from that in others. Among 100 cancers invading the muscularis propria, depressed-types in 15, cyclooxygenase-2 expression was not detected in depressed-types; these were significantly smaller lesions than those in others (p<0.05). Our results suggest that depressed-type cancers do not result from cyclooxygenase-2 expression.

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Nov-Dec 2000
Volume 7 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Saito K, Arai K and Mori M: Cyclooxygenase-2 immunoreactivity in depressed-type colorectal adenomas and cancers.. Oncol Rep 7: 1217-1226, 2000
APA
Saito, K., Arai, K., & Mori, M. (2000). Cyclooxygenase-2 immunoreactivity in depressed-type colorectal adenomas and cancers.. Oncology Reports, 7, 1217-1226. https://doi.org/10.3892/or.7.6.1217
MLA
Saito, K., Arai, K., Mori, M."Cyclooxygenase-2 immunoreactivity in depressed-type colorectal adenomas and cancers.". Oncology Reports 7.6 (2000): 1217-1226.
Chicago
Saito, K., Arai, K., Mori, M."Cyclooxygenase-2 immunoreactivity in depressed-type colorectal adenomas and cancers.". Oncology Reports 7, no. 6 (2000): 1217-1226. https://doi.org/10.3892/or.7.6.1217