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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Nov-Dec 2000 Volume 7 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Antitumor effects of fotemustine and busulfan against a human neuroblastoma xenograft.

  • Authors:
    • H Ikeda
    • Y Tsuchida
    • J Wu
    • N Suzuki
    • M Kuroiwa
    • S H Choi
    • A Morikawa

  • View Affiliations / Copyright

    Affiliations: The Department of Surgery, Gunma Children's Medical Center, Hokkitsu, Seta-gun, Gunma 377-8577, Japan.
  • Pages: 1265-1273
    |
    Published online on: November 1, 2000
       https://doi.org/10.3892/or.7.6.1265
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Abstract

We examined whether or not fotemustine, a new nitrosourea derivative, and busulfan, an agent already clinically used, are effective against human neuroblastoma, using a human neuroblastoma xenograft model designated TNB9. The maximum inhibition rate (MIR) of fotemustine against the TNB9 model was 44.6% with a total dose of fotemustine of 75 mg/kg, indicating that fotemustine is not effective against TNB9. The MIR of busulfan against the same model was 26.7% when a total dose of 135 mg/kg was administered orally to nude mice. Busulfan was also suspended in carboxy-methylcellulose, and was administered intraperitoneally. The MIRs were 19.4% and 36. 4% when busulfan was administered intraperitoneally at a total dose of 40 mg/kg and 60 mg/kg, respectively. The total doses of 40 mg/kg and 60 mg/kg did not show any adverse effects on mice, but were found to be ineffective against TNB9, indicating that busulfan might not be an effective chemotherapeutic agent against human neuroblastoma.

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Copy and paste a formatted citation
Spandidos Publications style
Ikeda H, Tsuchida Y, Wu J, Suzuki N, Kuroiwa M, Choi S and Morikawa A: Antitumor effects of fotemustine and busulfan against a human neuroblastoma xenograft.. Oncol Rep 7: 1265-1273, 2000.
APA
Ikeda, H., Tsuchida, Y., Wu, J., Suzuki, N., Kuroiwa, M., Choi, S., & Morikawa, A. (2000). Antitumor effects of fotemustine and busulfan against a human neuroblastoma xenograft.. Oncology Reports, 7, 1265-1273. https://doi.org/10.3892/or.7.6.1265
MLA
Ikeda, H., Tsuchida, Y., Wu, J., Suzuki, N., Kuroiwa, M., Choi, S., Morikawa, A."Antitumor effects of fotemustine and busulfan against a human neuroblastoma xenograft.". Oncology Reports 7.6 (2000): 1265-1273.
Chicago
Ikeda, H., Tsuchida, Y., Wu, J., Suzuki, N., Kuroiwa, M., Choi, S., Morikawa, A."Antitumor effects of fotemustine and busulfan against a human neuroblastoma xenograft.". Oncology Reports 7, no. 6 (2000): 1265-1273. https://doi.org/10.3892/or.7.6.1265
Copy and paste a formatted citation
x
Spandidos Publications style
Ikeda H, Tsuchida Y, Wu J, Suzuki N, Kuroiwa M, Choi S and Morikawa A: Antitumor effects of fotemustine and busulfan against a human neuroblastoma xenograft.. Oncol Rep 7: 1265-1273, 2000.
APA
Ikeda, H., Tsuchida, Y., Wu, J., Suzuki, N., Kuroiwa, M., Choi, S., & Morikawa, A. (2000). Antitumor effects of fotemustine and busulfan against a human neuroblastoma xenograft.. Oncology Reports, 7, 1265-1273. https://doi.org/10.3892/or.7.6.1265
MLA
Ikeda, H., Tsuchida, Y., Wu, J., Suzuki, N., Kuroiwa, M., Choi, S., Morikawa, A."Antitumor effects of fotemustine and busulfan against a human neuroblastoma xenograft.". Oncology Reports 7.6 (2000): 1265-1273.
Chicago
Ikeda, H., Tsuchida, Y., Wu, J., Suzuki, N., Kuroiwa, M., Choi, S., Morikawa, A."Antitumor effects of fotemustine and busulfan against a human neuroblastoma xenograft.". Oncology Reports 7, no. 6 (2000): 1265-1273. https://doi.org/10.3892/or.7.6.1265
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