Adenosine receptor antagonism causes inhibition of angiogenic activity of human ovarian cancer cells.

  • Authors:
    • E Barcz
    • E Sommer
    • P Janik
    • L Marianowski
    • E Skopinska-Rózewska
  • View Affiliations

  • Published online on: November 1, 2000     https://doi.org/10.3892/or.7.6.1285
  • Pages: 1285-1376
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Abstract

Angiogenesis, new blood vessels development, is an important process involved in ovarian cancer growth and metastasis. Adenosine is a known mediator of angiogenesis in hypoxic tissues. Theobromine, adenosine receptor antagonist, exerts antiangiogenic properties in many types of tumors in Balb/c mice cutaneous angiogenesis assay. The aim of the present study was to evaluate the mechanism of its action. We showed that theobromine inhibits angiogenic activity of ovarian cancer cells as well as CD45 positive lymphocytes isolated from peritoneal ascitic fluid of ovarian cancer patients. Using synthetic adenosine receptor antagonists: 8-phenyl-theophylline and 8-cyclopentyl-1,3 dipropylxantine we established that antiangiogenic properties of theobromine are dependent on its interaction with A2 adenosine receptor. Our observations were confirmed in full suspensions of ascitic cells as well as in isolated cancer cells and CD45 lymphocytes. We postulate that A2 receptor antagonism may diminish angiogenesis induced by hypoxia in different cancer tissues and may find a place in future cancer therapy.

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Nov-Dec 2000
Volume 7 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Barcz E, Sommer E, Janik P, Marianowski L and Skopinska-Rózewska E: Adenosine receptor antagonism causes inhibition of angiogenic activity of human ovarian cancer cells.. Oncol Rep 7: 1285-1376, 2000
APA
Barcz, E., Sommer, E., Janik, P., Marianowski, L., & Skopinska-Rózewska, E. (2000). Adenosine receptor antagonism causes inhibition of angiogenic activity of human ovarian cancer cells.. Oncology Reports, 7, 1285-1376. https://doi.org/10.3892/or.7.6.1285
MLA
Barcz, E., Sommer, E., Janik, P., Marianowski, L., Skopinska-Rózewska, E."Adenosine receptor antagonism causes inhibition of angiogenic activity of human ovarian cancer cells.". Oncology Reports 7.6 (2000): 1285-1376.
Chicago
Barcz, E., Sommer, E., Janik, P., Marianowski, L., Skopinska-Rózewska, E."Adenosine receptor antagonism causes inhibition of angiogenic activity of human ovarian cancer cells.". Oncology Reports 7, no. 6 (2000): 1285-1376. https://doi.org/10.3892/or.7.6.1285