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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Nov-Dec 2000 Volume 7 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Adenosine receptor antagonism causes inhibition of angiogenic activity of human ovarian cancer cells.

  • Authors:
    • E Barcz
    • E Sommer
    • P Janik
    • L Marianowski
    • E Skopinska-Rózewska
  • View Affiliations / Copyright

    Affiliations: First Department of Obstetrics and Gynaecology, The Medical University of Warsaw, 02-015 Warsaw, Poland.
  • Pages: 1285-1376
    |
    Published online on: November 1, 2000
       https://doi.org/10.3892/or.7.6.1285
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Abstract

Angiogenesis, new blood vessels development, is an important process involved in ovarian cancer growth and metastasis. Adenosine is a known mediator of angiogenesis in hypoxic tissues. Theobromine, adenosine receptor antagonist, exerts antiangiogenic properties in many types of tumors in Balb/c mice cutaneous angiogenesis assay. The aim of the present study was to evaluate the mechanism of its action. We showed that theobromine inhibits angiogenic activity of ovarian cancer cells as well as CD45 positive lymphocytes isolated from peritoneal ascitic fluid of ovarian cancer patients. Using synthetic adenosine receptor antagonists: 8-phenyl-theophylline and 8-cyclopentyl-1,3 dipropylxantine we established that antiangiogenic properties of theobromine are dependent on its interaction with A2 adenosine receptor. Our observations were confirmed in full suspensions of ascitic cells as well as in isolated cancer cells and CD45 lymphocytes. We postulate that A2 receptor antagonism may diminish angiogenesis induced by hypoxia in different cancer tissues and may find a place in future cancer therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Barcz E, Sommer E, Janik P, Marianowski L and Skopinska-Rózewska E: Adenosine receptor antagonism causes inhibition of angiogenic activity of human ovarian cancer cells.. Oncol Rep 7: 1285-1376, 2000.
APA
Barcz, E., Sommer, E., Janik, P., Marianowski, L., & Skopinska-Rózewska, E. (2000). Adenosine receptor antagonism causes inhibition of angiogenic activity of human ovarian cancer cells.. Oncology Reports, 7, 1285-1376. https://doi.org/10.3892/or.7.6.1285
MLA
Barcz, E., Sommer, E., Janik, P., Marianowski, L., Skopinska-Rózewska, E."Adenosine receptor antagonism causes inhibition of angiogenic activity of human ovarian cancer cells.". Oncology Reports 7.6 (2000): 1285-1376.
Chicago
Barcz, E., Sommer, E., Janik, P., Marianowski, L., Skopinska-Rózewska, E."Adenosine receptor antagonism causes inhibition of angiogenic activity of human ovarian cancer cells.". Oncology Reports 7, no. 6 (2000): 1285-1376. https://doi.org/10.3892/or.7.6.1285
Copy and paste a formatted citation
x
Spandidos Publications style
Barcz E, Sommer E, Janik P, Marianowski L and Skopinska-Rózewska E: Adenosine receptor antagonism causes inhibition of angiogenic activity of human ovarian cancer cells.. Oncol Rep 7: 1285-1376, 2000.
APA
Barcz, E., Sommer, E., Janik, P., Marianowski, L., & Skopinska-Rózewska, E. (2000). Adenosine receptor antagonism causes inhibition of angiogenic activity of human ovarian cancer cells.. Oncology Reports, 7, 1285-1376. https://doi.org/10.3892/or.7.6.1285
MLA
Barcz, E., Sommer, E., Janik, P., Marianowski, L., Skopinska-Rózewska, E."Adenosine receptor antagonism causes inhibition of angiogenic activity of human ovarian cancer cells.". Oncology Reports 7.6 (2000): 1285-1376.
Chicago
Barcz, E., Sommer, E., Janik, P., Marianowski, L., Skopinska-Rózewska, E."Adenosine receptor antagonism causes inhibition of angiogenic activity of human ovarian cancer cells.". Oncology Reports 7, no. 6 (2000): 1285-1376. https://doi.org/10.3892/or.7.6.1285
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