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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Nov-Dec 2000 Volume 7 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Bolus and infusional 5-fluorouracil combined with cisplatin in advanced gastric cancer.

  • Authors:
    • C Barone
    • A Cassano
    • M Landriscina
    • R Longo
    • A Astone
    • C Pozzo

  • View Affiliations / Copyright

    Affiliations: Oncologia Medica, Universita Cattolica del S. Cuore, Rome, Italy. oncologiamedica@unicatt.it
  • Pages: 1305-1314
    |
    Published online on: November 1, 2000
       https://doi.org/10.3892/or.7.6.1305
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Abstract

5-Fluorouracil (5-FU) is the main drug used in the treatment of advanced gastric cancer. Combination chemotherapy is not always superior to 5-FU alone, especially when biomodulators are also administered. In an attempt to exploit all the cytotoxic mechanisms of 5-FU, we carried out a pilot study with a double route of administration of 5-FU (intravenous bolus and continuous infusion) and a multiple modulation of 5-FU by methotrexate (MTX), 6S-leucovorin (6S-LV) and cisplatin (CDDP). A group of 30 patients affected by advanced gastric cancer was treated with MTX 50 mg/m2 and 5-FU 400 mg/m2 as an i.v. bolus on day 1, followed by a 5 day i. v. continuous infusion of 5-FU 600 mg/m2/day and 6S-LV 100 mg/m2/day; on day 3 CDDP 100 mg/m2 was also administered. The regimen was repeated every 4 weeks. Six partial responses (20+/-14. 3%), 12 stable diseases (40+/-17.5%) and 12 progression (40+/-17.5%) were observed in an intent-to-treat analysis. Median survival was 7 months. All responding patients had performance status 0-1. Grade 3-4 toxicity was mainly gastrointestinal, but grade 3-4 anemia and leucopenia were also recorded. The schedule has low activity. The use of different modulators and way of administration of 5-FU does not provide advantages in advanced gastric cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Barone C, Cassano A, Landriscina M, Longo R, Astone A and Pozzo C: Bolus and infusional 5-fluorouracil combined with cisplatin in advanced gastric cancer.. Oncol Rep 7: 1305-1314, 2000.
APA
Barone, C., Cassano, A., Landriscina, M., Longo, R., Astone, A., & Pozzo, C. (2000). Bolus and infusional 5-fluorouracil combined with cisplatin in advanced gastric cancer.. Oncology Reports, 7, 1305-1314. https://doi.org/10.3892/or.7.6.1305
MLA
Barone, C., Cassano, A., Landriscina, M., Longo, R., Astone, A., Pozzo, C."Bolus and infusional 5-fluorouracil combined with cisplatin in advanced gastric cancer.". Oncology Reports 7.6 (2000): 1305-1314.
Chicago
Barone, C., Cassano, A., Landriscina, M., Longo, R., Astone, A., Pozzo, C."Bolus and infusional 5-fluorouracil combined with cisplatin in advanced gastric cancer.". Oncology Reports 7, no. 6 (2000): 1305-1314. https://doi.org/10.3892/or.7.6.1305
Copy and paste a formatted citation
x
Spandidos Publications style
Barone C, Cassano A, Landriscina M, Longo R, Astone A and Pozzo C: Bolus and infusional 5-fluorouracil combined with cisplatin in advanced gastric cancer.. Oncol Rep 7: 1305-1314, 2000.
APA
Barone, C., Cassano, A., Landriscina, M., Longo, R., Astone, A., & Pozzo, C. (2000). Bolus and infusional 5-fluorouracil combined with cisplatin in advanced gastric cancer.. Oncology Reports, 7, 1305-1314. https://doi.org/10.3892/or.7.6.1305
MLA
Barone, C., Cassano, A., Landriscina, M., Longo, R., Astone, A., Pozzo, C."Bolus and infusional 5-fluorouracil combined with cisplatin in advanced gastric cancer.". Oncology Reports 7.6 (2000): 1305-1314.
Chicago
Barone, C., Cassano, A., Landriscina, M., Longo, R., Astone, A., Pozzo, C."Bolus and infusional 5-fluorouracil combined with cisplatin in advanced gastric cancer.". Oncology Reports 7, no. 6 (2000): 1305-1314. https://doi.org/10.3892/or.7.6.1305
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