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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Nov-Dec 2000 Volume 7 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer.

  • Authors:
    • M Yuki
    • K Yoshinaga
    • H Yamakawa
    • K Sakurada
    • S Sato
    • A Yajima
    • A Horii

  • View Affiliations / Copyright

    Affiliations: Department of Molecular Pathology, Tohoku University School of Medicine, Aoba-ku, Sendai 980-8575, Japan.
  • Pages: 1339-1381
    |
    Published online on: November 1, 2000
       https://doi.org/10.3892/or.7.6.1339
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Abstract

We previously reported that chromosome arm 10q is one of the target regions of allelic loss in human endometrial cancer. To identify the gene in this region responsible for endometrial cancer, we further characterized this region and localized the hBRAG gene. The function of hBRAG has not yet been fully studied, and there is the possibility that this gene works as a tumor suppressor. This gene consist of 7 exons and 6 introns encoding 503 amino acids; all the introns start with GT and end with AG in agreement with the GT-AG rule. Expression of this gene was studied by Northern hybridization and suppressed expression was observed in one (SK-UT-1B) of the six endometrial cancer cell lines. Mutation analysis in 38 primary EC tissues and six EC cell lines disclosed no genetic alterations. The genomic structure of hBRAG elucidated in this study should contribute to the future analysis of the hBRAG gene.

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Copy and paste a formatted citation
Spandidos Publications style
Yuki M, Yoshinaga K, Yamakawa H, Sakurada K, Sato S, Yajima A and Horii A: Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer.. Oncol Rep 7: 1339-1381, 2000.
APA
Yuki, M., Yoshinaga, K., Yamakawa, H., Sakurada, K., Sato, S., Yajima, A., & Horii, A. (2000). Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer.. Oncology Reports, 7, 1339-1381. https://doi.org/10.3892/or.7.6.1339
MLA
Yuki, M., Yoshinaga, K., Yamakawa, H., Sakurada, K., Sato, S., Yajima, A., Horii, A."Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer.". Oncology Reports 7.6 (2000): 1339-1381.
Chicago
Yuki, M., Yoshinaga, K., Yamakawa, H., Sakurada, K., Sato, S., Yajima, A., Horii, A."Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer.". Oncology Reports 7, no. 6 (2000): 1339-1381. https://doi.org/10.3892/or.7.6.1339
Copy and paste a formatted citation
x
Spandidos Publications style
Yuki M, Yoshinaga K, Yamakawa H, Sakurada K, Sato S, Yajima A and Horii A: Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer.. Oncol Rep 7: 1339-1381, 2000.
APA
Yuki, M., Yoshinaga, K., Yamakawa, H., Sakurada, K., Sato, S., Yajima, A., & Horii, A. (2000). Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer.. Oncology Reports, 7, 1339-1381. https://doi.org/10.3892/or.7.6.1339
MLA
Yuki, M., Yoshinaga, K., Yamakawa, H., Sakurada, K., Sato, S., Yajima, A., Horii, A."Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer.". Oncology Reports 7.6 (2000): 1339-1381.
Chicago
Yuki, M., Yoshinaga, K., Yamakawa, H., Sakurada, K., Sato, S., Yajima, A., Horii, A."Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer.". Oncology Reports 7, no. 6 (2000): 1339-1381. https://doi.org/10.3892/or.7.6.1339
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