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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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Nov-Dec 2000 Volume 7 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract.

  • Authors:
    • M A Caligo
    • C Ghimenti
    • E Sensi
    • A Marchetti
    • G Bertacca
    • P G Giulianotti
    • G Fornaciari
    • G Bevilacqua

  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Division of Pathology, Labaratory of Molecular Genetics, University of Pisa, I-56126 Pisa, Italy. m.caligo@do.med.unipi.it
  • Pages: 1371-1376
    |
    Published online on: November 1, 2000
       https://doi.org/10.3892/or.7.6.1371
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Abstract

DNA was analyzed from 57 sporadic gastrointestinal tumors (34 pancreatic cancers, 23 colon tumors) and cognate normal tissues to verify whether mutations at coding sequences were associated with microsatellite instability (MSI). Genomic instability was present in 41% (14/34) of pancreatic samples and in 26% (6/23) of colon cancers previously tested by six microsatellite markers. The tumors included 37 cases showing no MSI; 15 cases with MSI at only 1 locus and 5 cases with MSI at 2 or more loci. All the samples were screened for mutations in genes containing repeated tracts in their coding sequences (TGFbetaRII, IGFRII and bax) and in codon 12 of the K-ras oncogene. Furthermore, loss of heterozygosity (LOH) at NM23.H1 locus was tested, 17/34 (50%) pancreatic tumors and 6/23 (26%) colon cancers showed mutations in codon 12 of K-ras; allelic loss of NM23. H1 locus was found in 6/18 (33%) informative colon tumors and in no pancreatic cancers. The TGFbetaRII, IGFRII and bax genes were altered in 3 (13%), 1 (4%) and 3 (13%) out of 23 colon tumors respectively, but no mutation was detected in pancreatic cancers. Mutations in the repeated nucleotide stretches within the coding sequences of TGFbetaRII, IGFRII and bax genes were found only in colon tumors with a high unstable phenotype (more than 3 microsatellite loci altered).

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Copy and paste a formatted citation
Spandidos Publications style
Caligo M, Ghimenti C, Sensi E, Marchetti A, Bertacca G, Giulianotti P, Fornaciari G and Bevilacqua G: Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract.. Oncol Rep 7: 1371-1376, 2000.
APA
Caligo, M., Ghimenti, C., Sensi, E., Marchetti, A., Bertacca, G., Giulianotti, P. ... Bevilacqua, G. (2000). Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract.. Oncology Reports, 7, 1371-1376. https://doi.org/10.3892/or.7.6.1371
MLA
Caligo, M., Ghimenti, C., Sensi, E., Marchetti, A., Bertacca, G., Giulianotti, P., Fornaciari, G., Bevilacqua, G."Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract.". Oncology Reports 7.6 (2000): 1371-1376.
Chicago
Caligo, M., Ghimenti, C., Sensi, E., Marchetti, A., Bertacca, G., Giulianotti, P., Fornaciari, G., Bevilacqua, G."Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract.". Oncology Reports 7, no. 6 (2000): 1371-1376. https://doi.org/10.3892/or.7.6.1371
Copy and paste a formatted citation
x
Spandidos Publications style
Caligo M, Ghimenti C, Sensi E, Marchetti A, Bertacca G, Giulianotti P, Fornaciari G and Bevilacqua G: Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract.. Oncol Rep 7: 1371-1376, 2000.
APA
Caligo, M., Ghimenti, C., Sensi, E., Marchetti, A., Bertacca, G., Giulianotti, P. ... Bevilacqua, G. (2000). Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract.. Oncology Reports, 7, 1371-1376. https://doi.org/10.3892/or.7.6.1371
MLA
Caligo, M., Ghimenti, C., Sensi, E., Marchetti, A., Bertacca, G., Giulianotti, P., Fornaciari, G., Bevilacqua, G."Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract.". Oncology Reports 7.6 (2000): 1371-1376.
Chicago
Caligo, M., Ghimenti, C., Sensi, E., Marchetti, A., Bertacca, G., Giulianotti, P., Fornaciari, G., Bevilacqua, G."Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract.". Oncology Reports 7, no. 6 (2000): 1371-1376. https://doi.org/10.3892/or.7.6.1371
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