Expression of thrombospondin-1 inversely correlated with tumor vascularity and hematogenous metastasis in colon cancer

  • Authors:
    • K. Maeda
    • Y. Nishiguchi
    • Soon-Myoung Kang
    • M. Yashiro
    • N. Onoda
    • T. Sawada
    • T. Ishikawa
    • K. Hirakawa
  • View Affiliations

  • Published online on: July 1, 2001     https://doi.org/10.3892/or.8.4.763
  • Pages: 763-766
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Abstract

Solid tumors require neovascularization for growth and metastasis. Angiogenesis depends on the local balance between various molecules that induce and inhibit neovascularization. Thrombospondin-1 (TSP-1) is thought to be an antiangiogenic factor. In this study, we examined the correlation between expression of TSP-1 and tumor vascularity, and determined its prognostic significance in colon cancer. Microvessel density, determined by immunostaining for factor VIII-related antigen, was significantly higher in tumors that were TSP-1-negative. TSP-1 expression was inversely correlated with prognosis. Patients with TSP-1-negative tumors had a significantly worse prognosis than did those with TSP-1-positive tumors. Frequency of hepatic recurrence was significantly higher in patients with tumors that were TSP-1-negative. In conclusion, TSP-1 is an important negative-regulator of tumor angiogenesis, and TSP-1 may be useful for predicting recurrence in patients with colon cancer.

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July-August 2001
Volume 8 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Maeda K, Nishiguchi Y, Kang S, Yashiro M, Onoda N, Sawada T, Ishikawa T and Hirakawa K: Expression of thrombospondin-1 inversely correlated with tumor vascularity and hematogenous metastasis in colon cancer. Oncol Rep 8: 763-766, 2001
APA
Maeda, K., Nishiguchi, Y., Kang, S., Yashiro, M., Onoda, N., Sawada, T. ... Hirakawa, K. (2001). Expression of thrombospondin-1 inversely correlated with tumor vascularity and hematogenous metastasis in colon cancer. Oncology Reports, 8, 763-766. https://doi.org/10.3892/or.8.4.763
MLA
Maeda, K., Nishiguchi, Y., Kang, S., Yashiro, M., Onoda, N., Sawada, T., Ishikawa, T., Hirakawa, K."Expression of thrombospondin-1 inversely correlated with tumor vascularity and hematogenous metastasis in colon cancer". Oncology Reports 8.4 (2001): 763-766.
Chicago
Maeda, K., Nishiguchi, Y., Kang, S., Yashiro, M., Onoda, N., Sawada, T., Ishikawa, T., Hirakawa, K."Expression of thrombospondin-1 inversely correlated with tumor vascularity and hematogenous metastasis in colon cancer". Oncology Reports 8, no. 4 (2001): 763-766. https://doi.org/10.3892/or.8.4.763