Effect of human urinary macrophage colony-stimulating factor on the immune functions and the blood cell counts in patients with ovarian carcinoma receiving cytotoxic chemotherapy

  • Authors:
    • Yoshio Shimizu
    • Kuniko Utsugi
    • Satoshi Umezawa
    • Kahori Shimizu
    • Katsuhiko Hasumi
    • Mitsuaki Suzuki
    • Fumimaro Takaku
  • View Affiliations

  • Published online on: July 1, 2001     https://doi.org/10.3892/or.8.4.767
  • Pages: 767-772
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Abstract

The present study investigated the effect of macrophage colony-stimulating factor (M-CSF) on the immune functions and blood cell counts of patients with ovarian carcinoma receiving cytotoxic chemotherapy (CTX). Seventy-five consecutive patients with white blood cell counts less than 3,000/μl after CTX were randomly assigned to receive either M-CSF (human urinary macrophage colony-stimulating factor: hM-CSF, 8x106 U as 7-day intravenous infusions) or no treatment. Immune assays in addition to routine peripheral blood examinations were performed on these patients at various time points. hM-CSF dosing significantly increased monocyte, lymphocyte, granulocyte, and platelet counts that were decreased by CTX. hM-CSF also significantly enhanced lymphokine-activated killer and natural killer activities, which was accompanied by a significantly augmented interleukin (IL)-2 production. Interestingly, IL-2 production was enhanced by hM-CSF dosing in 24 of the 27 patients with a pre-hM-CSF level of IL-2 below 10 U/ml, but such an effect was not observed in nine of the 10 patients having a basal value of 10 U/ml or higher. Thus, hM-CSF is considered to be a cytokine that can augment or regulate immune functions impaired by CTX and increase blood cell counts that are decreased by CTX.

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July-August 2001
Volume 8 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Shimizu Y, Utsugi K, Umezawa S, Shimizu K, Hasumi K, Suzuki M and Takaku F: Effect of human urinary macrophage colony-stimulating factor on the immune functions and the blood cell counts in patients with ovarian carcinoma receiving cytotoxic chemotherapy. Oncol Rep 8: 767-772, 2001
APA
Shimizu, Y., Utsugi, K., Umezawa, S., Shimizu, K., Hasumi, K., Suzuki, M., & Takaku, F. (2001). Effect of human urinary macrophage colony-stimulating factor on the immune functions and the blood cell counts in patients with ovarian carcinoma receiving cytotoxic chemotherapy. Oncology Reports, 8, 767-772. https://doi.org/10.3892/or.8.4.767
MLA
Shimizu, Y., Utsugi, K., Umezawa, S., Shimizu, K., Hasumi, K., Suzuki, M., Takaku, F."Effect of human urinary macrophage colony-stimulating factor on the immune functions and the blood cell counts in patients with ovarian carcinoma receiving cytotoxic chemotherapy". Oncology Reports 8.4 (2001): 767-772.
Chicago
Shimizu, Y., Utsugi, K., Umezawa, S., Shimizu, K., Hasumi, K., Suzuki, M., Takaku, F."Effect of human urinary macrophage colony-stimulating factor on the immune functions and the blood cell counts in patients with ovarian carcinoma receiving cytotoxic chemotherapy". Oncology Reports 8, no. 4 (2001): 767-772. https://doi.org/10.3892/or.8.4.767