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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
July-August 2001 Volume 8 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July-August 2001 Volume 8 Issue 4

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Article

Correlation between EGF receptor expression and peplomycin cytotoxicity in squamous cell carcinoma cell lines

  • Authors:
    • Masayoshi Osaku
    • Masakazu Ueda
    • Takeshi Miyakawa
    • Hajime Toyoda
    • Kazuo Uesato
    • Yoshinori Yamada
    • Fumiki Asanuma
    • Nobuyoshi Ando
    • Soji Ozawa
    • Yuhkoh Kitagawa
    • Masaki Kitajima
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Kitasato Institute Hospital, Tokyo 108-8642, Japan
  • Pages: 855-860
    |
    Published online on: July 1, 2001
       https://doi.org/10.3892/or.8.4.855
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Abstract

The relationship between sensitivity to anti-cancer agents and EGF receptor expression on squamous cell carcinoma (SCC) cells was investigated. The cytotoxicity of peplomycin (PEP) was correlated with the number of the EGF receptors expressed on the cancer cells, but no correlations were found between the cytotoxicity of adriamycin and cisplatin and EGF receptors. Addition of TNFα increased the number of EGF receptors in the SCC cell lines 1.5- to 2-fold. The cytotoxic effect of combined administration of PEP and TNFα was correlated with the number of EGF receptors, and produced a 2- to 5-fold increase in IC50 compared with administration of PEP alone. These observations suggest that EGF receptor expression is closely associated with the cytotoxic effect of PEP on SCC cells.

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Copy and paste a formatted citation
Spandidos Publications style
Osaku M, Ueda M, Miyakawa T, Toyoda H, Uesato K, Yamada Y, Asanuma F, Ando N, Ozawa S, Kitagawa Y, Kitagawa Y, et al: Correlation between EGF receptor expression and peplomycin cytotoxicity in squamous cell carcinoma cell lines. Oncol Rep 8: 855-860, 2001.
APA
Osaku, M., Ueda, M., Miyakawa, T., Toyoda, H., Uesato, K., Yamada, Y. ... Kitajima, M. (2001). Correlation between EGF receptor expression and peplomycin cytotoxicity in squamous cell carcinoma cell lines. Oncology Reports, 8, 855-860. https://doi.org/10.3892/or.8.4.855
MLA
Osaku, M., Ueda, M., Miyakawa, T., Toyoda, H., Uesato, K., Yamada, Y., Asanuma, F., Ando, N., Ozawa, S., Kitagawa, Y., Kitajima, M."Correlation between EGF receptor expression and peplomycin cytotoxicity in squamous cell carcinoma cell lines". Oncology Reports 8.4 (2001): 855-860.
Chicago
Osaku, M., Ueda, M., Miyakawa, T., Toyoda, H., Uesato, K., Yamada, Y., Asanuma, F., Ando, N., Ozawa, S., Kitagawa, Y., Kitajima, M."Correlation between EGF receptor expression and peplomycin cytotoxicity in squamous cell carcinoma cell lines". Oncology Reports 8, no. 4 (2001): 855-860. https://doi.org/10.3892/or.8.4.855
Copy and paste a formatted citation
x
Spandidos Publications style
Osaku M, Ueda M, Miyakawa T, Toyoda H, Uesato K, Yamada Y, Asanuma F, Ando N, Ozawa S, Kitagawa Y, Kitagawa Y, et al: Correlation between EGF receptor expression and peplomycin cytotoxicity in squamous cell carcinoma cell lines. Oncol Rep 8: 855-860, 2001.
APA
Osaku, M., Ueda, M., Miyakawa, T., Toyoda, H., Uesato, K., Yamada, Y. ... Kitajima, M. (2001). Correlation between EGF receptor expression and peplomycin cytotoxicity in squamous cell carcinoma cell lines. Oncology Reports, 8, 855-860. https://doi.org/10.3892/or.8.4.855
MLA
Osaku, M., Ueda, M., Miyakawa, T., Toyoda, H., Uesato, K., Yamada, Y., Asanuma, F., Ando, N., Ozawa, S., Kitagawa, Y., Kitajima, M."Correlation between EGF receptor expression and peplomycin cytotoxicity in squamous cell carcinoma cell lines". Oncology Reports 8.4 (2001): 855-860.
Chicago
Osaku, M., Ueda, M., Miyakawa, T., Toyoda, H., Uesato, K., Yamada, Y., Asanuma, F., Ando, N., Ozawa, S., Kitagawa, Y., Kitajima, M."Correlation between EGF receptor expression and peplomycin cytotoxicity in squamous cell carcinoma cell lines". Oncology Reports 8, no. 4 (2001): 855-860. https://doi.org/10.3892/or.8.4.855
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