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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
January-February 2002 Volume 9 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-February 2002 Volume 9 Issue 1

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Article

Potentiated antitumor effects of butyrate and actinomycin D in melanoma model in mice

  • Authors:
    • Adam Giermasz
    • Marcin Makowski
    • Dominika Nowis
    • Ahmad Jalili
    • Malgorzata Maj
    • Anna Dabrowska
    • Anna Czajka
    • Marek Jakobisiak
    • Jakub Golab

  • View Affiliations / Copyright

    Affiliations: Department of Immunology, Center of Biostructure Research, The Medical University of Warsaw, 02-004 Warsaw, Poland
  • Pages: 199-203
    |
    Published online on: January 1, 2002
       https://doi.org/10.3892/or.9.1.199
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Abstract

Butyrate and butyric acid derivatives are well known to induce differentiation and apoptosis of tumor cells and have also recently gained acceptance as potential anticancer agents. In this study we observed an increased expression of mTNFα in tumor tissues in mice treated with butyrate prodrug tributyrin. Since in in vitro experiments we observed a potentiating effects of TNFα and actinomycin D on B16F10 cells and also a synergistic interaction was previously claimed between those agents, we investigated the anti-tumor activity of the combination therapy with butyrate and actinomycin D in the B16F10 melanoma model in mice. The combination of the drugs resulted in a strongly potentiated tumor growth retardation in melanoma bearing mice. However the B16F10 cells in vitro did not produce any detectable amounts of TNFα. The presented data strongly suggest that one of the mechanism of this successful drug combination could depend on the interaction of the actinomycin D with butyrate-induced TNFα produced by stromal or tumor infiltrating immune cells. The results illustrate also the possible application of this combination in cancer therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Giermasz A, Makowski M, Nowis D, Jalili A, Maj M, Dabrowska A, Czajka A, Jakobisiak M and Golab J: Potentiated antitumor effects of butyrate and actinomycin D in melanoma model in mice. Oncol Rep 9: 199-203, 2002.
APA
Giermasz, A., Makowski, M., Nowis, D., Jalili, A., Maj, M., Dabrowska, A. ... Golab, J. (2002). Potentiated antitumor effects of butyrate and actinomycin D in melanoma model in mice. Oncology Reports, 9, 199-203. https://doi.org/10.3892/or.9.1.199
MLA
Giermasz, A., Makowski, M., Nowis, D., Jalili, A., Maj, M., Dabrowska, A., Czajka, A., Jakobisiak, M., Golab, J."Potentiated antitumor effects of butyrate and actinomycin D in melanoma model in mice". Oncology Reports 9.1 (2002): 199-203.
Chicago
Giermasz, A., Makowski, M., Nowis, D., Jalili, A., Maj, M., Dabrowska, A., Czajka, A., Jakobisiak, M., Golab, J."Potentiated antitumor effects of butyrate and actinomycin D in melanoma model in mice". Oncology Reports 9, no. 1 (2002): 199-203. https://doi.org/10.3892/or.9.1.199
Copy and paste a formatted citation
x
Spandidos Publications style
Giermasz A, Makowski M, Nowis D, Jalili A, Maj M, Dabrowska A, Czajka A, Jakobisiak M and Golab J: Potentiated antitumor effects of butyrate and actinomycin D in melanoma model in mice. Oncol Rep 9: 199-203, 2002.
APA
Giermasz, A., Makowski, M., Nowis, D., Jalili, A., Maj, M., Dabrowska, A. ... Golab, J. (2002). Potentiated antitumor effects of butyrate and actinomycin D in melanoma model in mice. Oncology Reports, 9, 199-203. https://doi.org/10.3892/or.9.1.199
MLA
Giermasz, A., Makowski, M., Nowis, D., Jalili, A., Maj, M., Dabrowska, A., Czajka, A., Jakobisiak, M., Golab, J."Potentiated antitumor effects of butyrate and actinomycin D in melanoma model in mice". Oncology Reports 9.1 (2002): 199-203.
Chicago
Giermasz, A., Makowski, M., Nowis, D., Jalili, A., Maj, M., Dabrowska, A., Czajka, A., Jakobisiak, M., Golab, J."Potentiated antitumor effects of butyrate and actinomycin D in melanoma model in mice". Oncology Reports 9, no. 1 (2002): 199-203. https://doi.org/10.3892/or.9.1.199
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