Potentiated antitumor effects of butyrate and actinomycin D in melanoma model in mice

  • Authors:
    • Adam Giermasz
    • Marcin Makowski
    • Dominika Nowis
    • Ahmad Jalili
    • Malgorzata Maj
    • Anna Dabrowska
    • Anna Czajka
    • Marek Jakobisiak
    • Jakub Golab
  • View Affiliations

  • Published online on: January 1, 2002     https://doi.org/10.3892/or.9.1.199
  • Pages: 199-203
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Abstract

Butyrate and butyric acid derivatives are well known to induce differentiation and apoptosis of tumor cells and have also recently gained acceptance as potential anticancer agents. In this study we observed an increased expression of mTNFα in tumor tissues in mice treated with butyrate prodrug tributyrin. Since in in vitro experiments we observed a potentiating effects of TNFα and actinomycin D on B16F10 cells and also a synergistic interaction was previously claimed between those agents, we investigated the anti-tumor activity of the combination therapy with butyrate and actinomycin D in the B16F10 melanoma model in mice. The combination of the drugs resulted in a strongly potentiated tumor growth retardation in melanoma bearing mice. However the B16F10 cells in vitro did not produce any detectable amounts of TNFα. The presented data strongly suggest that one of the mechanism of this successful drug combination could depend on the interaction of the actinomycin D with butyrate-induced TNFα produced by stromal or tumor infiltrating immune cells. The results illustrate also the possible application of this combination in cancer therapy.

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January-February 2002
Volume 9 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Giermasz A, Makowski M, Nowis D, Jalili A, Maj M, Dabrowska A, Czajka A, Jakobisiak M and Golab J: Potentiated antitumor effects of butyrate and actinomycin D in melanoma model in mice. Oncol Rep 9: 199-203, 2002
APA
Giermasz, A., Makowski, M., Nowis, D., Jalili, A., Maj, M., Dabrowska, A. ... Golab, J. (2002). Potentiated antitumor effects of butyrate and actinomycin D in melanoma model in mice. Oncology Reports, 9, 199-203. https://doi.org/10.3892/or.9.1.199
MLA
Giermasz, A., Makowski, M., Nowis, D., Jalili, A., Maj, M., Dabrowska, A., Czajka, A., Jakobisiak, M., Golab, J."Potentiated antitumor effects of butyrate and actinomycin D in melanoma model in mice". Oncology Reports 9.1 (2002): 199-203.
Chicago
Giermasz, A., Makowski, M., Nowis, D., Jalili, A., Maj, M., Dabrowska, A., Czajka, A., Jakobisiak, M., Golab, J."Potentiated antitumor effects of butyrate and actinomycin D in melanoma model in mice". Oncology Reports 9, no. 1 (2002): 199-203. https://doi.org/10.3892/or.9.1.199