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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January-February 2002 Volume 9 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-February 2002 Volume 9 Issue 1

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Article

C-met and hepatocyte growth factor expression in combined hepatocellular and cholangiocarcinoma

  • Authors:
    • Heike Varnholt
    • Yoshiki Asayama
    • Shin-ichi Aishima
    • Ken-ichi Taguchi
    • Keishi Sugimachi
    • Masazumi Tsuneyoshi

  • View Affiliations / Copyright

    Affiliations: Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
  • Pages: 35-41
    |
    Published online on: January 1, 2002
       https://doi.org/10.3892/or.9.1.35
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Abstract

The membranous tyrosine kinase receptor c-met and its natural ligand hepatocyte growth factor are prominent mitogens, motogens and morphogens for hepatocytes and many other cell types in vitro as well as in vivo. To clarify the significance of the c-met/hepatocyte growth factor system in the development and spread of combined hepatocellular and cholangiocarcinoma, surgical specimen from 30 patients, consisting of 4 double cancers, 20 combined types and 6 mixed types, were examined immunohistochemically. Immunoreactivity for HGF was significantly correlated with the differentiation degree of cholangiocellular components, being highest in well and moderately differentiated and lowest in poorly differentiated components (p=0.0119). No significant association was observed between expression of c-met or HGF and the presence of liver cirrhosis, vascular invasion, perineural invasion, lymphatic permeation, intrahepatic metastasis or lymph node metastasis. HGF may have an important impact on the differentiation of certain cHCC-CC. Other clinicopathologic factors related to tumor development and spread may not be influenced by c-met or HGF, at least not on the protein level.

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Copy and paste a formatted citation
Spandidos Publications style
Varnholt H, Asayama Y, Aishima S, Taguchi K, Sugimachi K and Tsuneyoshi M: C-met and hepatocyte growth factor expression in combined hepatocellular and cholangiocarcinoma. Oncol Rep 9: 35-41, 2002.
APA
Varnholt, H., Asayama, Y., Aishima, S., Taguchi, K., Sugimachi, K., & Tsuneyoshi, M. (2002). C-met and hepatocyte growth factor expression in combined hepatocellular and cholangiocarcinoma. Oncology Reports, 9, 35-41. https://doi.org/10.3892/or.9.1.35
MLA
Varnholt, H., Asayama, Y., Aishima, S., Taguchi, K., Sugimachi, K., Tsuneyoshi, M."C-met and hepatocyte growth factor expression in combined hepatocellular and cholangiocarcinoma". Oncology Reports 9.1 (2002): 35-41.
Chicago
Varnholt, H., Asayama, Y., Aishima, S., Taguchi, K., Sugimachi, K., Tsuneyoshi, M."C-met and hepatocyte growth factor expression in combined hepatocellular and cholangiocarcinoma". Oncology Reports 9, no. 1 (2002): 35-41. https://doi.org/10.3892/or.9.1.35
Copy and paste a formatted citation
x
Spandidos Publications style
Varnholt H, Asayama Y, Aishima S, Taguchi K, Sugimachi K and Tsuneyoshi M: C-met and hepatocyte growth factor expression in combined hepatocellular and cholangiocarcinoma. Oncol Rep 9: 35-41, 2002.
APA
Varnholt, H., Asayama, Y., Aishima, S., Taguchi, K., Sugimachi, K., & Tsuneyoshi, M. (2002). C-met and hepatocyte growth factor expression in combined hepatocellular and cholangiocarcinoma. Oncology Reports, 9, 35-41. https://doi.org/10.3892/or.9.1.35
MLA
Varnholt, H., Asayama, Y., Aishima, S., Taguchi, K., Sugimachi, K., Tsuneyoshi, M."C-met and hepatocyte growth factor expression in combined hepatocellular and cholangiocarcinoma". Oncology Reports 9.1 (2002): 35-41.
Chicago
Varnholt, H., Asayama, Y., Aishima, S., Taguchi, K., Sugimachi, K., Tsuneyoshi, M."C-met and hepatocyte growth factor expression in combined hepatocellular and cholangiocarcinoma". Oncology Reports 9, no. 1 (2002): 35-41. https://doi.org/10.3892/or.9.1.35
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