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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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January-February 2002 Volume 9 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-February 2002 Volume 9 Issue 1

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Article

Treatment of advanced colorectal adenocarcinoma with weekly high-dose l-leucovorin and 5-fluorouracil

  • Authors:
    • Mutsumi Nozue
    • Naohide Isaka
    • Tsunehiko Maruyama
    • T. Kawamoto
    • K.-I. Seino
    • H. Tanagichi
    • K. Fukao

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
  • Pages: 93-96
    |
    Published online on: January 1, 2002
       https://doi.org/10.3892/or.9.1.93
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Abstract

We report the results of 5-fluorouracil (5-FU) combined with high-dose l-folinic acid (leucovorin) therapy for patients with advanced colorectal carcinoma. In each treatment course, the patients weekly received both 5-FU (600 mg/m2 by intravenous 15 min infusion) and l-folinic acid (250 mg/m2 by intravenous infusion over a period of 2 h). A total of six treatments were administered with a 14-day interval to the next course of six treatments. Forty-eight patients were evaluated for toxicity and 32 for response. The combined complete and partial response rate was 25% in 32 patients. Toxicity was within acceptable limits without grade 4 toxicity. Although the response rate was slightly lower than those reported in phase II trials in Japan, the result was satisfactory. This therapy can be the standard chemotherapy for colorectal cancer patients, even in Japan.

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Copy and paste a formatted citation
Spandidos Publications style
Nozue M, Isaka N, Maruyama T, Kawamoto T, Seino K, Tanagichi H and Fukao K: Treatment of advanced colorectal adenocarcinoma with weekly high-dose l-leucovorin and 5-fluorouracil. Oncol Rep 9: 93-96, 2002.
APA
Nozue, M., Isaka, N., Maruyama, T., Kawamoto, T., Seino, K., Tanagichi, H., & Fukao, K. (2002). Treatment of advanced colorectal adenocarcinoma with weekly high-dose l-leucovorin and 5-fluorouracil. Oncology Reports, 9, 93-96. https://doi.org/10.3892/or.9.1.93
MLA
Nozue, M., Isaka, N., Maruyama, T., Kawamoto, T., Seino, K., Tanagichi, H., Fukao, K."Treatment of advanced colorectal adenocarcinoma with weekly high-dose l-leucovorin and 5-fluorouracil". Oncology Reports 9.1 (2002): 93-96.
Chicago
Nozue, M., Isaka, N., Maruyama, T., Kawamoto, T., Seino, K., Tanagichi, H., Fukao, K."Treatment of advanced colorectal adenocarcinoma with weekly high-dose l-leucovorin and 5-fluorouracil". Oncology Reports 9, no. 1 (2002): 93-96. https://doi.org/10.3892/or.9.1.93
Copy and paste a formatted citation
x
Spandidos Publications style
Nozue M, Isaka N, Maruyama T, Kawamoto T, Seino K, Tanagichi H and Fukao K: Treatment of advanced colorectal adenocarcinoma with weekly high-dose l-leucovorin and 5-fluorouracil. Oncol Rep 9: 93-96, 2002.
APA
Nozue, M., Isaka, N., Maruyama, T., Kawamoto, T., Seino, K., Tanagichi, H., & Fukao, K. (2002). Treatment of advanced colorectal adenocarcinoma with weekly high-dose l-leucovorin and 5-fluorouracil. Oncology Reports, 9, 93-96. https://doi.org/10.3892/or.9.1.93
MLA
Nozue, M., Isaka, N., Maruyama, T., Kawamoto, T., Seino, K., Tanagichi, H., Fukao, K."Treatment of advanced colorectal adenocarcinoma with weekly high-dose l-leucovorin and 5-fluorouracil". Oncology Reports 9.1 (2002): 93-96.
Chicago
Nozue, M., Isaka, N., Maruyama, T., Kawamoto, T., Seino, K., Tanagichi, H., Fukao, K."Treatment of advanced colorectal adenocarcinoma with weekly high-dose l-leucovorin and 5-fluorouracil". Oncology Reports 9, no. 1 (2002): 93-96. https://doi.org/10.3892/or.9.1.93
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