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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March-April 2002 Volume 9 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Differential expression of heat shock protein 27 in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma

  • Authors:
    • Rosy Leonardi
    • Giuseppe Pannone
    • Gaetano Magro
    • Yasusei Kudo
    • Takashi Takata
    • Lorenzo Lo Muzio

  • View Affiliations / Copyright

    Affiliations: Department of Medical and Surgical Sciences, II Dental Unit, University of Catania, Catania, Italy
  • Pages: 261-266
    |
    Published online on: March 1, 2002
       https://doi.org/10.3892/or.9.2.261
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Abstract

The aim of this study was to evaluate HSP27 expression in fetal, normal and inflammed oral mucosal epithelium and in oral premalignant epithelial lesions and in their ensuing invasive cancers. In developing human oral epithelia, immunoreactions for HSP27 were moderately observed in suprabasal keratinocytes of palate and tongue. Normal oral epithelium had an intense suprabasal positivity. In inflammed oral mucosa, HSP27 staining was stronger in basal and suprabasal keratinocytes than in normal epithelium. Most oral premalignant lesions showed no (5 cases, 29%) or low (8 cases, 46.4%) staining. In OSCC both low and high HSP27 levels of expression were observed. HSP27 immunolabelling was down-regulated in poorly differentiated areas and up-regulated in highly differentiated ones. These findings indicated that HSP27 expression seems to protect cells from apoptosis during inflammation, while the down-regulation in dysplasia could impair the protective mechanism against mutagenesis induced by environmental factors and thus enhancing the transformation of oral epithelial dysplasia into OSCCs.

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Copy and paste a formatted citation
Spandidos Publications style
Leonardi R, Pannone G, Magro G, Kudo Y, Takata T and Lo Muzio L: Differential expression of heat shock protein 27 in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma. Oncol Rep 9: 261-266, 2002.
APA
Leonardi, R., Pannone, G., Magro, G., Kudo, Y., Takata, T., & Lo Muzio, L. (2002). Differential expression of heat shock protein 27 in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma. Oncology Reports, 9, 261-266. https://doi.org/10.3892/or.9.2.261
MLA
Leonardi, R., Pannone, G., Magro, G., Kudo, Y., Takata, T., Lo Muzio, L."Differential expression of heat shock protein 27 in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma". Oncology Reports 9.2 (2002): 261-266.
Chicago
Leonardi, R., Pannone, G., Magro, G., Kudo, Y., Takata, T., Lo Muzio, L."Differential expression of heat shock protein 27 in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma". Oncology Reports 9, no. 2 (2002): 261-266. https://doi.org/10.3892/or.9.2.261
Copy and paste a formatted citation
x
Spandidos Publications style
Leonardi R, Pannone G, Magro G, Kudo Y, Takata T and Lo Muzio L: Differential expression of heat shock protein 27 in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma. Oncol Rep 9: 261-266, 2002.
APA
Leonardi, R., Pannone, G., Magro, G., Kudo, Y., Takata, T., & Lo Muzio, L. (2002). Differential expression of heat shock protein 27 in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma. Oncology Reports, 9, 261-266. https://doi.org/10.3892/or.9.2.261
MLA
Leonardi, R., Pannone, G., Magro, G., Kudo, Y., Takata, T., Lo Muzio, L."Differential expression of heat shock protein 27 in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma". Oncology Reports 9.2 (2002): 261-266.
Chicago
Leonardi, R., Pannone, G., Magro, G., Kudo, Y., Takata, T., Lo Muzio, L."Differential expression of heat shock protein 27 in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma". Oncology Reports 9, no. 2 (2002): 261-266. https://doi.org/10.3892/or.9.2.261
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