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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March-April 2002 Volume 9 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March-April 2002 Volume 9 Issue 2

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Article

Cyclic AMP-dependent secretion of Ca 19-9 by LS174T human colon carcinoma cells

  • Authors:
    • Vincenzo Macchia
    • Maria Gargiulo
    • Daniela Terracciano
    • Angelina Di Carlo
    • Angela Mariano

  • View Affiliations / Copyright

    Affiliations: Dipartimento di Biologia e Patologia Cellulare e Molecolare <L. Califano>, Universita di Napoli <Federico II>, I-80131 Napoli, Italy. macchia@unina.it
  • Pages: 387-391
    |
    Published online on: March 1, 2002
       https://doi.org/10.3892/or.9.2.387
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Abstract

Prolonged increase of cyclic adenosine-monophosphate (cAMP) level in culture medium of a human colon cancer cell (LS174T) inhibits cellular growth and stimulates Ca 19-9 expression. The raise in cAMP level was produced by dibutyryl cyclic AMP (DBcAMP) or by forskolin an agent acting at the level of cAMP generation. Both these agents in a range of concentration between 10-3-10-5 M have an inhibitory effect on the growth which is dose and time dependent. The inhibition was reversible as demonstrated by complete restoration of cell growth soon after the withdrawal of the substances from the culture medium. When cAMP levels in culture medium was raised, an increase in Ca 19-9 expression was observed and it appears that cyclic nucleotides have at least two effects: the first to cause rapid release of already synthesized Ca 19-9 and second to stimulate new antigen synthesis. The findings of the present study demonstrated that LS174T cells are unable to proliferate upon sustained accumulation of intracellular cyclic AMP suggesting the use of strategies able to increase cAMP levels for therapy of colon cancer. Furthermore, the finding that cAMP may also be a regulator of Ca 19-9 synthesis and release indicates the utility of cell line LS174T as a model for studies on the mechanism of synthesis and secretion of specific tumoral markers in colon cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Macchia V, Gargiulo M, Terracciano D, Di Carlo A and Mariano A: Cyclic AMP-dependent secretion of Ca 19-9 by LS174T human colon carcinoma cells. Oncol Rep 9: 387-391, 2002.
APA
Macchia, V., Gargiulo, M., Terracciano, D., Di Carlo, A., & Mariano, A. (2002). Cyclic AMP-dependent secretion of Ca 19-9 by LS174T human colon carcinoma cells. Oncology Reports, 9, 387-391. https://doi.org/10.3892/or.9.2.387
MLA
Macchia, V., Gargiulo, M., Terracciano, D., Di Carlo, A., Mariano, A."Cyclic AMP-dependent secretion of Ca 19-9 by LS174T human colon carcinoma cells". Oncology Reports 9.2 (2002): 387-391.
Chicago
Macchia, V., Gargiulo, M., Terracciano, D., Di Carlo, A., Mariano, A."Cyclic AMP-dependent secretion of Ca 19-9 by LS174T human colon carcinoma cells". Oncology Reports 9, no. 2 (2002): 387-391. https://doi.org/10.3892/or.9.2.387
Copy and paste a formatted citation
x
Spandidos Publications style
Macchia V, Gargiulo M, Terracciano D, Di Carlo A and Mariano A: Cyclic AMP-dependent secretion of Ca 19-9 by LS174T human colon carcinoma cells. Oncol Rep 9: 387-391, 2002.
APA
Macchia, V., Gargiulo, M., Terracciano, D., Di Carlo, A., & Mariano, A. (2002). Cyclic AMP-dependent secretion of Ca 19-9 by LS174T human colon carcinoma cells. Oncology Reports, 9, 387-391. https://doi.org/10.3892/or.9.2.387
MLA
Macchia, V., Gargiulo, M., Terracciano, D., Di Carlo, A., Mariano, A."Cyclic AMP-dependent secretion of Ca 19-9 by LS174T human colon carcinoma cells". Oncology Reports 9.2 (2002): 387-391.
Chicago
Macchia, V., Gargiulo, M., Terracciano, D., Di Carlo, A., Mariano, A."Cyclic AMP-dependent secretion of Ca 19-9 by LS174T human colon carcinoma cells". Oncology Reports 9, no. 2 (2002): 387-391. https://doi.org/10.3892/or.9.2.387
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