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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
July-August 2002 Volume 9 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-August 2002 Volume 9 Issue 4

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Article

Association of matrilysin expression with progression and poor prognosis in human pancreatic adenocarcinoma

  • Authors:
    • Hideaki Nakamura
    • Shouichi Horita
    • Naoto Senmaru
    • Yuichi Miyasaka
    • Takayuki Gohda
    • Yoshiyuki Inoue
    • Miyoshi Fujita
    • Takashi Meguro
    • Takayuki Morita
    • Kazuro Nagashima

  • View Affiliations / Copyright

    Affiliations: Internal Medicine, Hokkaido Shoukakika Hospital, Sapporo 065-0042, Japan. pv2h-nkmr@asahi-net.or.jp
  • Pages: 751-755
    |
    Published online on: July 1, 2002
       https://doi.org/10.3892/or.9.4.751
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Abstract

The matrix metalloproteinase matrilysin has been implicated in the progression of gastrointestinal and other cancers. The aim of this study was to determine whether matrilysin has clinicopathological and prognostic significance in pancreatic carcinoma. Using immunohistochemistry, we analyzed 39 pancreatic adenocarcinoma tissues for expression of matrilysin. The results were matched with clinicopathological characteristics and patient survival. The relationship of matrilysin expression with p53 expression or cellular proliferation determined by Ki-67 expression was also investigated. Sections with immunostaining signals in more than 30% of carcinoma cells at the invasive front, which were observed in 25 (64%) cases, were judged to be positive for matrilysin. Matrilysin positivity was significantly correlated with infiltrating growth pattern, lymph node metastasis, and postoperative recurrence. Expression of matrilysin was not correlated with either Ki-67 or p53 expression. Patients with matrilysin-positive carcinoma had a significantly shorter overall survival time than did those with matrilysin-negative carcinoma. Our results suggest that matrilysin plays a key role in the progression of pancreatic carcinoma.

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Copy and paste a formatted citation
Spandidos Publications style
Nakamura H, Horita S, Senmaru N, Miyasaka Y, Gohda T, Inoue Y, Fujita M, Meguro T, Morita T, Nagashima K, Nagashima K, et al: Association of matrilysin expression with progression and poor prognosis in human pancreatic adenocarcinoma. Oncol Rep 9: 751-755, 2002.
APA
Nakamura, H., Horita, S., Senmaru, N., Miyasaka, Y., Gohda, T., Inoue, Y. ... Nagashima, K. (2002). Association of matrilysin expression with progression and poor prognosis in human pancreatic adenocarcinoma. Oncology Reports, 9, 751-755. https://doi.org/10.3892/or.9.4.751
MLA
Nakamura, H., Horita, S., Senmaru, N., Miyasaka, Y., Gohda, T., Inoue, Y., Fujita, M., Meguro, T., Morita, T., Nagashima, K."Association of matrilysin expression with progression and poor prognosis in human pancreatic adenocarcinoma". Oncology Reports 9.4 (2002): 751-755.
Chicago
Nakamura, H., Horita, S., Senmaru, N., Miyasaka, Y., Gohda, T., Inoue, Y., Fujita, M., Meguro, T., Morita, T., Nagashima, K."Association of matrilysin expression with progression and poor prognosis in human pancreatic adenocarcinoma". Oncology Reports 9, no. 4 (2002): 751-755. https://doi.org/10.3892/or.9.4.751
Copy and paste a formatted citation
x
Spandidos Publications style
Nakamura H, Horita S, Senmaru N, Miyasaka Y, Gohda T, Inoue Y, Fujita M, Meguro T, Morita T, Nagashima K, Nagashima K, et al: Association of matrilysin expression with progression and poor prognosis in human pancreatic adenocarcinoma. Oncol Rep 9: 751-755, 2002.
APA
Nakamura, H., Horita, S., Senmaru, N., Miyasaka, Y., Gohda, T., Inoue, Y. ... Nagashima, K. (2002). Association of matrilysin expression with progression and poor prognosis in human pancreatic adenocarcinoma. Oncology Reports, 9, 751-755. https://doi.org/10.3892/or.9.4.751
MLA
Nakamura, H., Horita, S., Senmaru, N., Miyasaka, Y., Gohda, T., Inoue, Y., Fujita, M., Meguro, T., Morita, T., Nagashima, K."Association of matrilysin expression with progression and poor prognosis in human pancreatic adenocarcinoma". Oncology Reports 9.4 (2002): 751-755.
Chicago
Nakamura, H., Horita, S., Senmaru, N., Miyasaka, Y., Gohda, T., Inoue, Y., Fujita, M., Meguro, T., Morita, T., Nagashima, K."Association of matrilysin expression with progression and poor prognosis in human pancreatic adenocarcinoma". Oncology Reports 9, no. 4 (2002): 751-755. https://doi.org/10.3892/or.9.4.751
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