Expression of survivin correlated with vessel invasion is a marker of poor prognosis in small adenocarcinoma of the lung

Ikehara,Mizuki; Oshita,Fumihiro; Kameda,Yoichi; Ito,Hiroyuki; Ohgane,Naoki; Suzuki,Rie; Saito,Haruhiro; Yamada,Kouzo; Noda,Kazumasa; Mitsuda,Aki

doi:10.3892/or.9.4.835

July-August 2002 Volume 9 Issue 4

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July-August 2002 Volume 9 Issue 4

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Article

Expression of survivin correlated with vessel invasion is a marker of poor prognosis in small adenocarcinoma of the lung

Authors:
- Mizuki Ikehara
- Fumihiro Oshita
- Yoichi Kameda
- Hiroyuki Ito
- Naoki Ohgane
- Rie Suzuki
- Haruhiro Saito
- Kouzo Yamada
- Kazumasa Noda
- Aki Mitsuda
View Affiliations / Copyright

Affiliations: Department of Thoracic Oncology, Kanagawa Cancer Center, Asahi-ku, Yokohama 241-0815, Japan
Pages: 835-838
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Published online on: July 1, 2002

https://doi.org/10.3892/or.9.4.835
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Abstract

The purpose of this study was to investigate the possible association between expression of survivin, pathological findings in the tumor and survival in patients with small adenocarcinoma of the lung. Seventy-nine patients with resected tumors <2 cm in diameter were entered into the study. There were 33 males and 46 females, with a median age of 64 years (range 26-83 years). The pathological stage of the tumors was recorded as stage I, II, III and IV in 72, one, five and one case, respectively. Each patient underwent curative surgical resection for lung cancer between July 1992 and November 1999. The resected tumors were subjected to immunostaining for survivin. Thirty-eight patients had tumors with ≤10% survivin-positive cells and 41 patients had tumors with >10% survivin-positive cells. When survivin expression and pathological findings in the resected tumors were analyzed, the frequency of venous invasion was significantly higher in the survivin-positive group (36.6% vs. 13.2%; p=0.0167). In contrast, the overall survival of survivin-positive patients (n=41) was significantly worse than that of individuals whose tumors were negative for survivin expression (n=38; log-rank test, p=0.014; Wilcoxon test, p=0.021). It can be concluded that the expression of survivin in tumor cells is a factor of poor prognosis in patients with small adenocarcinoma of the lung.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression of survivin correlated with vessel invasion is a marker of poor prognosis in small adenocarcinoma of the lung

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Abstract

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