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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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July-August 2002 Volume 9 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Enhanced nucleotide excision repair in cisplatin resistant human KB carcinoma cells

  • Authors:
    • Motoi Mukai
    • Atsuko Kanzaki
    • Zhe-Sheng Chen
    • Hitoshi Miyashita
    • Tomoyuki Sumizawa
    • Tatsuhiko Furukawa
    • Misako Haraguchi
    • Yuji Takebayashi
    • Hideo Takamatsu
    • Shin-Ichi Akiyama

  • View Affiliations / Copyright

    Affiliations: Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
  • Pages: 839-844
    |
    Published online on: July 1, 2002
       https://doi.org/10.3892/or.9.4.839
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Abstract

We previously reported that enhanced active efflux of cisplatin and increased GSH level were observed in KCP-4 cells. In the present study, KCP-4 cells were found to be cross-resistant to ultraviolet (UV) compared with parental KB-3-1 cells. Enhanced nucleotide excision repair (NER) was verified by time-dependent repair of UV-induced DNA damage. In addition, the amount of platinum bound to DNA after exposure to cisplatin decreased in a time-dependent manner in KCP-4 cells and this was reversed by aphidicolin, a DNA polymerase inhibitor. In stationary phase cultures, aphidicolin increased the sensitivity of KCP-4 cells to cisplatin. The expression of xeroderma pigmentosum complementation group F (XPF), an endonuclease involved in NER, was upregulated in KCP-4 cells. In KCP-4 cells the expression of hMSH6, one of the mismatch repair (MMR) factors, was decreased compared to parental KB-3-1 and revertant KCP-4R cells. However, KCP-4 cells were cross-resistant to oxaliplatin, and microsatellite instability was not observed in them. These findings suggest that the enhanced NER activity for DNA damage caused by cisplatin may be involved in cisplatin resistance in KCP-4 cells.

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Copy and paste a formatted citation
Spandidos Publications style
Mukai M, Kanzaki A, Chen Z, Miyashita H, Sumizawa T, Furukawa T, Haraguchi M, Takebayashi Y, Takamatsu H, Akiyama S, Akiyama S, et al: Enhanced nucleotide excision repair in cisplatin resistant human KB carcinoma cells. Oncol Rep 9: 839-844, 2002.
APA
Mukai, M., Kanzaki, A., Chen, Z., Miyashita, H., Sumizawa, T., Furukawa, T. ... Akiyama, S. (2002). Enhanced nucleotide excision repair in cisplatin resistant human KB carcinoma cells. Oncology Reports, 9, 839-844. https://doi.org/10.3892/or.9.4.839
MLA
Mukai, M., Kanzaki, A., Chen, Z., Miyashita, H., Sumizawa, T., Furukawa, T., Haraguchi, M., Takebayashi, Y., Takamatsu, H., Akiyama, S."Enhanced nucleotide excision repair in cisplatin resistant human KB carcinoma cells". Oncology Reports 9.4 (2002): 839-844.
Chicago
Mukai, M., Kanzaki, A., Chen, Z., Miyashita, H., Sumizawa, T., Furukawa, T., Haraguchi, M., Takebayashi, Y., Takamatsu, H., Akiyama, S."Enhanced nucleotide excision repair in cisplatin resistant human KB carcinoma cells". Oncology Reports 9, no. 4 (2002): 839-844. https://doi.org/10.3892/or.9.4.839
Copy and paste a formatted citation
x
Spandidos Publications style
Mukai M, Kanzaki A, Chen Z, Miyashita H, Sumizawa T, Furukawa T, Haraguchi M, Takebayashi Y, Takamatsu H, Akiyama S, Akiyama S, et al: Enhanced nucleotide excision repair in cisplatin resistant human KB carcinoma cells. Oncol Rep 9: 839-844, 2002.
APA
Mukai, M., Kanzaki, A., Chen, Z., Miyashita, H., Sumizawa, T., Furukawa, T. ... Akiyama, S. (2002). Enhanced nucleotide excision repair in cisplatin resistant human KB carcinoma cells. Oncology Reports, 9, 839-844. https://doi.org/10.3892/or.9.4.839
MLA
Mukai, M., Kanzaki, A., Chen, Z., Miyashita, H., Sumizawa, T., Furukawa, T., Haraguchi, M., Takebayashi, Y., Takamatsu, H., Akiyama, S."Enhanced nucleotide excision repair in cisplatin resistant human KB carcinoma cells". Oncology Reports 9.4 (2002): 839-844.
Chicago
Mukai, M., Kanzaki, A., Chen, Z., Miyashita, H., Sumizawa, T., Furukawa, T., Haraguchi, M., Takebayashi, Y., Takamatsu, H., Akiyama, S."Enhanced nucleotide excision repair in cisplatin resistant human KB carcinoma cells". Oncology Reports 9, no. 4 (2002): 839-844. https://doi.org/10.3892/or.9.4.839
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