Basic fibroblast growth factor mediated growth inhibition in breast cancer cells is independent of ras signaling pathway

Fenig,Eyal; Szyper-Kravitz,Martin; Yerushalmi,Rinat; Lahav,Meir; Beery,Einat; Wasserman,Lina; Gutman,Haim; Nordenberg,Jardena

doi:10.3892/or.9.4.875

July-August 2002 Volume 9 Issue 4

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July-August 2002 Volume 9 Issue 4

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Article

Basic fibroblast growth factor mediated growth inhibition in breast cancer cells is independent of ras signaling pathway

Authors:
- Eyal Fenig
- Martin Szyper-Kravitz
- Rinat Yerushalmi
- Meir Lahav
- Einat Beery
- Lina Wasserman
- Haim Gutman
- Jardena Nordenberg
View Affiliations / Copyright

Affiliations: Institute of Oncology, Rabin Medical Center, Beilinson Campus, Petah Tiqva 49100, Israel. efenig@clalit.org.il
Pages: 875-877
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Published online on: July 1, 2002

https://doi.org/10.3892/or.9.4.875
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Abstract

Our previous studies have demonstrated that basic fibroblast growth factor (bFGF) inhibits the growth of MCF-7 human breast cancer cells via binding to high affinity cell surface receptors. The downstream signaling of bFGF was reported to involve the ras pathway. The aim of the present study was to examine the bFGF-induced growth inhibition in the presence of lovastatin, a farnesyl transferase inhibitor, which impaired ras signaling by preventing its association with the plasma membrane. We found that the combined cytotoxicity induced by lovastatin and bFGF was greater than the cytotoxicity induced by each agent alone. Similarly, the protein level of P21/WAF1/cip1 was greater after exposure to both agents together, than separately. bFGF did not interfere with the lovastatin-induced inhibition of P21/RAS membrane association, while lovastatin did not prevent MAPK activation by bFGF. Based on these findings we suggest that the growth inhibitory effect of bFGF on breast cancer cells is largely independent of the ras signaling pathway. Understanding these pathways may enable active intervention to alter the therapeutic ratio favorably in the treatment of breast cancer.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Basic fibroblast growth factor mediated growth inhibition in breast cancer cells is independent of ras signaling pathway

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