Paradoxical effects by preoperative oral low-dose tegafur administration in human gastric carcinomas: Enhanced apoptosis and increased intratumoral microvessel density

  • Authors:
    • Eizo Goto
    • Eiji Okamoto
    • Hironobu Adachi
    • Yasuhiko Fukuda
    • Hisao Ito
  • View Affiliations

  • Published online on: September 1, 2002     https://doi.org/10.3892/or.9.5.1021
  • Pages: 1021-1026
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Abstract

This study examined the effect of preoperative low-dose tegafur treatment in human gastric carcinomas. Among 55 patients with gastric carcinoma, 33 received an oral administration of tegafur 600 mg/body/day for 7 days before. Formalin-fixed, paraffin-embedded specimens were immunostained for Ki-67, P53, P21, CD34, Bax, VEGF, and dThdPase and also examined by the terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling procedure. The apoptotic index (AI), Ki-67 labeling index (KI) and intratumoral microvessel density (IMVD) were counted. Mean AI and IMVD were 3.4±1.60 and 126.1±36.56 in the treated carcinomas, and 2.3±0.88 and 98.0±44.40 in the non-treated carcinomas, both values being significantly higher in the former (P<0.05). The treatment resulted in a significant increase of mean AI in the intestinal type, in the early, and in the P53-positive carcinomas (P<0.05), while the treatment brought a significant increase of IMVD in the diffuse type, in the early and in the P53-negative carcinomas (P<0.05, respectively). No significant difference was noted on the frequency of P53, P21, BAX, VEGF and dThdPase expressions between the two groups. Ki-67 expression did not correlate with any factors. Preoperative low-dose tegafur treatment resulted in a paradoxical effect; enhanced apoptosis and increased IMVD in human gastric carcinomas.

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September-October 2002
Volume 9 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Goto E, Okamoto E, Adachi H, Fukuda Y and Ito H: Paradoxical effects by preoperative oral low-dose tegafur administration in human gastric carcinomas: Enhanced apoptosis and increased intratumoral microvessel density. Oncol Rep 9: 1021-1026, 2002
APA
Goto, E., Okamoto, E., Adachi, H., Fukuda, Y., & Ito, H. (2002). Paradoxical effects by preoperative oral low-dose tegafur administration in human gastric carcinomas: Enhanced apoptosis and increased intratumoral microvessel density. Oncology Reports, 9, 1021-1026. https://doi.org/10.3892/or.9.5.1021
MLA
Goto, E., Okamoto, E., Adachi, H., Fukuda, Y., Ito, H."Paradoxical effects by preoperative oral low-dose tegafur administration in human gastric carcinomas: Enhanced apoptosis and increased intratumoral microvessel density". Oncology Reports 9.5 (2002): 1021-1026.
Chicago
Goto, E., Okamoto, E., Adachi, H., Fukuda, Y., Ito, H."Paradoxical effects by preoperative oral low-dose tegafur administration in human gastric carcinomas: Enhanced apoptosis and increased intratumoral microvessel density". Oncology Reports 9, no. 5 (2002): 1021-1026. https://doi.org/10.3892/or.9.5.1021