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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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September-October 2002 Volume 9 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Retinoblastoma-related gene RB2/p130 exons 19-22 are rarely mutated in glioblastomas

  • Authors:
    • P. Gonzalez-Gomez
    • M. J. Bello
    • D. Arjona
    • M. E. Alonso
    • J. Lomas
    • J. M. De Campos
    • J. Vaquero
    • A. Isla
    • M. Gutierrez
    • J. A. Rey

  • View Affiliations / Copyright

    Affiliations: Laboratorio de Oncogenetica Molecular, Departamento C. Experimental, Hospital Universitario La Paz, 28046 Madrid, Spain
  • Pages: 951-954
    |
    Published online on: September 1, 2002
       https://doi.org/10.3892/or.9.5.951
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Abstract

The retinoblastoma gene family RB1, p107 and RB2/p130 cooperate to regulate cell cycle progression through the G1 phase of the cell cycle. Previous data demonstrated that RB2/p130 inhibits proliferation of the glioblastoma cell line T98G, which is resistant to the growth suppressive effects of both RB1 and p107, and that RB2/p130 gene overexpresion induces astrocyte differentiation. We screened by single-strand conformation polymorphism and sequence analysis the structure of exons 19 trough 22 of the RB2/p130 gene, which encodes the B domain and C terminus, in a series of 42 glioblastomas (32 primary and 10 secondary). Sequence variations were identified in one tumor, suggesting that mutation inactivation of RB2/p130 is a rare event in glioblastoma.

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Copy and paste a formatted citation
Spandidos Publications style
Gonzalez-Gomez P, Bello MJ, Arjona D, Alonso ME, Lomas J, De Campos JM, Vaquero J, Isla A, Gutierrez M, Rey JA, Rey JA, et al: Retinoblastoma-related gene RB2/p130 exons 19-22 are rarely mutated in glioblastomas. Oncol Rep 9: 951-954, 2002.
APA
Gonzalez-Gomez, P., Bello, M.J., Arjona, D., Alonso, M.E., Lomas, J., De Campos, J.M. ... Rey, J.A. (2002). Retinoblastoma-related gene RB2/p130 exons 19-22 are rarely mutated in glioblastomas. Oncology Reports, 9, 951-954. https://doi.org/10.3892/or.9.5.951
MLA
Gonzalez-Gomez, P., Bello, M. J., Arjona, D., Alonso, M. E., Lomas, J., De Campos, J. M., Vaquero, J., Isla, A., Gutierrez, M., Rey, J. A."Retinoblastoma-related gene RB2/p130 exons 19-22 are rarely mutated in glioblastomas". Oncology Reports 9.5 (2002): 951-954.
Chicago
Gonzalez-Gomez, P., Bello, M. J., Arjona, D., Alonso, M. E., Lomas, J., De Campos, J. M., Vaquero, J., Isla, A., Gutierrez, M., Rey, J. A."Retinoblastoma-related gene RB2/p130 exons 19-22 are rarely mutated in glioblastomas". Oncology Reports 9, no. 5 (2002): 951-954. https://doi.org/10.3892/or.9.5.951
Copy and paste a formatted citation
x
Spandidos Publications style
Gonzalez-Gomez P, Bello MJ, Arjona D, Alonso ME, Lomas J, De Campos JM, Vaquero J, Isla A, Gutierrez M, Rey JA, Rey JA, et al: Retinoblastoma-related gene RB2/p130 exons 19-22 are rarely mutated in glioblastomas. Oncol Rep 9: 951-954, 2002.
APA
Gonzalez-Gomez, P., Bello, M.J., Arjona, D., Alonso, M.E., Lomas, J., De Campos, J.M. ... Rey, J.A. (2002). Retinoblastoma-related gene RB2/p130 exons 19-22 are rarely mutated in glioblastomas. Oncology Reports, 9, 951-954. https://doi.org/10.3892/or.9.5.951
MLA
Gonzalez-Gomez, P., Bello, M. J., Arjona, D., Alonso, M. E., Lomas, J., De Campos, J. M., Vaquero, J., Isla, A., Gutierrez, M., Rey, J. A."Retinoblastoma-related gene RB2/p130 exons 19-22 are rarely mutated in glioblastomas". Oncology Reports 9.5 (2002): 951-954.
Chicago
Gonzalez-Gomez, P., Bello, M. J., Arjona, D., Alonso, M. E., Lomas, J., De Campos, J. M., Vaquero, J., Isla, A., Gutierrez, M., Rey, J. A."Retinoblastoma-related gene RB2/p130 exons 19-22 are rarely mutated in glioblastomas". Oncology Reports 9, no. 5 (2002): 951-954. https://doi.org/10.3892/or.9.5.951
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