VEGF-C expression correlates with histological differentiation and metastasis in squamous cell carcinoma of the esophagus

  • Authors:
    • Tsuyoshi Noguchi
    • Shinsuke Takeno
    • Tomotaka Shibata
    • Yuzo Uchida
    • Shigeo Yokoyama
    • Wolfram Muller
  • View Affiliations

  • Published online on: September 1, 2002     https://doi.org/10.3892/or.9.5.995
  • Pages: 995-999
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Abstract

Vascular endothelial growth factor C (VEGF-C) is known to act in lymphangiogenesis. Recent reports suggest VEGF-C plays a role in the spread of several cancers to the lymph system. Lymphatic spread is a critical prognostic factor in esophageal cancer, however, the molecular mechanism involved in the spread of cancerous cells remains unclear. In the present study the clinicopathological implication of VEGF-C was analyzed using immunohistochemistry. Seventy-one patients with esophageal squamous cell carcinoma (ESCC) resected in our institute were included in this study. Formalin-fixed paraffin-embedded specimens were stained for VEGF-C and the correlation between the staining, its clinicopathological parameters and its prognostic power were analyzed statistically. Only histological grade (differentiation) was shown to have a statistically significant correlation with VEGF-C expression (p=0.028). Age (p=0.064), lymph node metastasis (pN) (p=0.085) and vascular invasion (p=0.092) tended to correlate with VEGF-C expression although on analysis this correlation was not statistically significant. The results suggested there is no prognostic implication for VEGF-C in ESCC (p=0.80). There is no significant correlation between VEGF-C expression and clinicopathological parameters involved in lymphatic spread. However, VEGF-C expression might play an important role in metastasis of ESCC since histological grade was closely related to lymph node metastasis and distant metastasis.

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September-October 2002
Volume 9 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Noguchi T, Takeno S, Shibata T, Uchida Y, Yokoyama S and Muller W: VEGF-C expression correlates with histological differentiation and metastasis in squamous cell carcinoma of the esophagus. Oncol Rep 9: 995-999, 2002
APA
Noguchi, T., Takeno, S., Shibata, T., Uchida, Y., Yokoyama, S., & Muller, W. (2002). VEGF-C expression correlates with histological differentiation and metastasis in squamous cell carcinoma of the esophagus. Oncology Reports, 9, 995-999. https://doi.org/10.3892/or.9.5.995
MLA
Noguchi, T., Takeno, S., Shibata, T., Uchida, Y., Yokoyama, S., Muller, W."VEGF-C expression correlates with histological differentiation and metastasis in squamous cell carcinoma of the esophagus". Oncology Reports 9.5 (2002): 995-999.
Chicago
Noguchi, T., Takeno, S., Shibata, T., Uchida, Y., Yokoyama, S., Muller, W."VEGF-C expression correlates with histological differentiation and metastasis in squamous cell carcinoma of the esophagus". Oncology Reports 9, no. 5 (2002): 995-999. https://doi.org/10.3892/or.9.5.995