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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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November-December 2002 Volume 9 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November-December 2002 Volume 9 Issue 6

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Article

Expression of drug resistance gene products during progression of lung carcinomas

  • Authors:
    • Jürgen Mattern
    • Reet Koomägi
    • Manfred Volm

  • View Affiliations / Copyright

    Affiliations: Department E0600, German Cancer Research Center, D-69120 Heidelberg, Germany. j.mattern@dkfz.de
  • Pages: 1181-1184
    |
    Published online on: November 1, 2002
       https://doi.org/10.3892/or.9.6.1181
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Abstract

In order to study whether the presence of mechanisms of drug resistance is a characteristic unique to advanced lung cancer or occurs already early in the course of the disease, we investigated the expression of gluathione S-transferase-π (GST-π), P-glycoprotein (P-gp) and metallothionein (MT) in 80 human lung carcinomas and in 20 normal lung tissues using immunohistochemistry. We found that all three proteins were expressed in resected normal lung and lung carcinomas. Expression of GST-π and MT was elevated in tumor tissues in comparison to normal lung tissues, whereas P-gp was highly expressed in normal lung. GST-π and MT expression increased with increasing tumor volume and differentiation grade. These results suggest that the level of GST-π and MT in lung cells increases as cells progress from the normal to the transformed state and that drug resistance gene products are already present in lung carcinomas at the time of surgical resection.

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Copy and paste a formatted citation
Spandidos Publications style
Mattern J, Koomägi R and Volm M: Expression of drug resistance gene products during progression of lung carcinomas. Oncol Rep 9: 1181-1184, 2002.
APA
Mattern, J., Koomägi, R., & Volm, M. (2002). Expression of drug resistance gene products during progression of lung carcinomas. Oncology Reports, 9, 1181-1184. https://doi.org/10.3892/or.9.6.1181
MLA
Mattern, J., Koomägi, R., Volm, M."Expression of drug resistance gene products during progression of lung carcinomas". Oncology Reports 9.6 (2002): 1181-1184.
Chicago
Mattern, J., Koomägi, R., Volm, M."Expression of drug resistance gene products during progression of lung carcinomas". Oncology Reports 9, no. 6 (2002): 1181-1184. https://doi.org/10.3892/or.9.6.1181
Copy and paste a formatted citation
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Spandidos Publications style
Mattern J, Koomägi R and Volm M: Expression of drug resistance gene products during progression of lung carcinomas. Oncol Rep 9: 1181-1184, 2002.
APA
Mattern, J., Koomägi, R., & Volm, M. (2002). Expression of drug resistance gene products during progression of lung carcinomas. Oncology Reports, 9, 1181-1184. https://doi.org/10.3892/or.9.6.1181
MLA
Mattern, J., Koomägi, R., Volm, M."Expression of drug resistance gene products during progression of lung carcinomas". Oncology Reports 9.6 (2002): 1181-1184.
Chicago
Mattern, J., Koomägi, R., Volm, M."Expression of drug resistance gene products during progression of lung carcinomas". Oncology Reports 9, no. 6 (2002): 1181-1184. https://doi.org/10.3892/or.9.6.1181
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