Expression of drug resistance gene products during progression of lung carcinomas

  • Authors:
    • Jürgen Mattern
    • Reet Koomägi
    • Manfred Volm
  • View Affiliations

  • Published online on: November 1, 2002     https://doi.org/10.3892/or.9.6.1181
  • Pages: 1181-1184
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Abstract

In order to study whether the presence of mechanisms of drug resistance is a characteristic unique to advanced lung cancer or occurs already early in the course of the disease, we investigated the expression of gluathione S-transferase-π (GST-π), P-glycoprotein (P-gp) and metallothionein (MT) in 80 human lung carcinomas and in 20 normal lung tissues using immunohistochemistry. We found that all three proteins were expressed in resected normal lung and lung carcinomas. Expression of GST-π and MT was elevated in tumor tissues in comparison to normal lung tissues, whereas P-gp was highly expressed in normal lung. GST-π and MT expression increased with increasing tumor volume and differentiation grade. These results suggest that the level of GST-π and MT in lung cells increases as cells progress from the normal to the transformed state and that drug resistance gene products are already present in lung carcinomas at the time of surgical resection.

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November-December 2002
Volume 9 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Mattern J, Koomägi R and Volm M: Expression of drug resistance gene products during progression of lung carcinomas. Oncol Rep 9: 1181-1184, 2002
APA
Mattern, J., Koomägi, R., & Volm, M. (2002). Expression of drug resistance gene products during progression of lung carcinomas. Oncology Reports, 9, 1181-1184. https://doi.org/10.3892/or.9.6.1181
MLA
Mattern, J., Koomägi, R., Volm, M."Expression of drug resistance gene products during progression of lung carcinomas". Oncology Reports 9.6 (2002): 1181-1184.
Chicago
Mattern, J., Koomägi, R., Volm, M."Expression of drug resistance gene products during progression of lung carcinomas". Oncology Reports 9, no. 6 (2002): 1181-1184. https://doi.org/10.3892/or.9.6.1181