Elevated preoperative serum ICTP is a prognostic factor for overall and disease-free survival in breast cancer

  • Authors:
    • Riitta Keskikuru
    • Risto Bloigu
    • Juha Risteli
    • Vesa Kataja
    • Arja Jukkola
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  • Published online on: November 1, 2002     https://doi.org/10.3892/or.9.6.1323
  • Pages: 1323-1327
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Abstract

The aim of this study was to evaluate the prognostic value of preoperative concentrations of the serum markers of type I collagen synthesis (PINP, PICP) and degradation (ICTP) in breast cancer. One hundred and eighty-four breast cancer patients without advanced disease were enrolled. Preoperative serum markers of type I collagen were assessed with specific radioimmunoassays. Elevated preoperative serum concentrations of ICTP (>4.9 μg/l) correlated statistically significantly with a poor prognosis for the breast cancer (P=0.0004) and shorter disease-free survival (P=0.02), and multivariate regression analysis likewise showed an elevated ICTP concentration (P=0.008), high grade (P=0.03) and high pathological stage (P=0.02) to be risk factors for poor survival. Sixty-five out of the 184 patients developed metastatic disease during the follow-up. The median follow-up time was 62 months (range 6-111 months). High ICTP (P=0.02) and large numbers of metastatic nodules (P=0.002) were prognostic factors for shorter disease-free survival in multivariate regression analysis. PINP and PICP had no significant prognostic value with respect to either overall or disease-free survival in this analysis. Our results indicate that preoperatively elevated serum ICTP is a prognostic factor in breast cancer, the measurement of which should improve the accuracy of predictions of the clinical outcome.

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November-December 2002
Volume 9 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Keskikuru R, Bloigu R, Risteli J, Kataja V and Jukkola A: Elevated preoperative serum ICTP is a prognostic factor for overall and disease-free survival in breast cancer. Oncol Rep 9: 1323-1327, 2002
APA
Keskikuru, R., Bloigu, R., Risteli, J., Kataja, V., & Jukkola, A. (2002). Elevated preoperative serum ICTP is a prognostic factor for overall and disease-free survival in breast cancer. Oncology Reports, 9, 1323-1327. https://doi.org/10.3892/or.9.6.1323
MLA
Keskikuru, R., Bloigu, R., Risteli, J., Kataja, V., Jukkola, A."Elevated preoperative serum ICTP is a prognostic factor for overall and disease-free survival in breast cancer". Oncology Reports 9.6 (2002): 1323-1327.
Chicago
Keskikuru, R., Bloigu, R., Risteli, J., Kataja, V., Jukkola, A."Elevated preoperative serum ICTP is a prognostic factor for overall and disease-free survival in breast cancer". Oncology Reports 9, no. 6 (2002): 1323-1327. https://doi.org/10.3892/or.9.6.1323