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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2009 Volume 21 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2009 Volume 21 Issue 2

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Article

Autocrine factors sustain glioblastoma stem cell self-renewal

  • Authors:
    • Guanghui Li
    • Zhengtang Chen
    • Yi-De Hu
    • Hong Wei
    • Dezhi Li
    • Hua Ji
    • Dong-Lin Wang

  • View Affiliations / Copyright

    Affiliations: Institute for Cancer Research in People's Liberation Army, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China
  • Pages: 419-424
    |
    Published online on: February 1, 2009
       https://doi.org/10.3892/or_00000239
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Abstract

Glioblastoma stem cells are able to reform original glioblastoma and express the neural stem cell marker CD133 and Nestin. They can self-renew and proliferate in tumor sphere medium containing EGF, bFGF and LIF that is known to be permissive for stem cell proliferation. In this study, we found that neurosphere-like colonies appeared after the human primary glioblastoma cells had been switched into pure DMEM/F12 medium. We investigated whether tumor spheres formed in pure DMEM/F12 medium possess the characteristics of glioblastoma stem cells. We identified that the tumor sphere cells were cancer stem cells of glioblastoma and they can self-renew and proliferate in pure DMEM/F12 medium. Glioblastoma cells can secrete several factors that result in autocrine motility signaling and stimulate glioma invasion. We hypothesized that an essential autocrine signal promotes the self-renewal and proliferation of human glioblastoma stem cells in pure DMEM/F12 medium. Then, expression of EGF and bFGF in glioblastoma stem cells were analyzed. Both the mRNA and protein of EGF and bFGF were detected in three human glioblastoma stem cells. Our findings suggest that autocrine of EGF and bFGF may sustain the self-renewal of glioblastoma stem cells.

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Copy and paste a formatted citation
Spandidos Publications style
Li G, Chen Z, Hu Y, Wei H, Li D, Ji H and Wang D: Autocrine factors sustain glioblastoma stem cell self-renewal. Oncol Rep 21: 419-424, 2009.
APA
Li, G., Chen, Z., Hu, Y., Wei, H., Li, D., Ji, H., & Wang, D. (2009). Autocrine factors sustain glioblastoma stem cell self-renewal. Oncology Reports, 21, 419-424. https://doi.org/10.3892/or_00000239
MLA
Li, G., Chen, Z., Hu, Y., Wei, H., Li, D., Ji, H., Wang, D."Autocrine factors sustain glioblastoma stem cell self-renewal". Oncology Reports 21.2 (2009): 419-424.
Chicago
Li, G., Chen, Z., Hu, Y., Wei, H., Li, D., Ji, H., Wang, D."Autocrine factors sustain glioblastoma stem cell self-renewal". Oncology Reports 21, no. 2 (2009): 419-424. https://doi.org/10.3892/or_00000239
Copy and paste a formatted citation
x
Spandidos Publications style
Li G, Chen Z, Hu Y, Wei H, Li D, Ji H and Wang D: Autocrine factors sustain glioblastoma stem cell self-renewal. Oncol Rep 21: 419-424, 2009.
APA
Li, G., Chen, Z., Hu, Y., Wei, H., Li, D., Ji, H., & Wang, D. (2009). Autocrine factors sustain glioblastoma stem cell self-renewal. Oncology Reports, 21, 419-424. https://doi.org/10.3892/or_00000239
MLA
Li, G., Chen, Z., Hu, Y., Wei, H., Li, D., Ji, H., Wang, D."Autocrine factors sustain glioblastoma stem cell self-renewal". Oncology Reports 21.2 (2009): 419-424.
Chicago
Li, G., Chen, Z., Hu, Y., Wei, H., Li, D., Ji, H., Wang, D."Autocrine factors sustain glioblastoma stem cell self-renewal". Oncology Reports 21, no. 2 (2009): 419-424. https://doi.org/10.3892/or_00000239
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