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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2009 Volume 21 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2009 Volume 21 Issue 2

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Article

Dynamic alteration of gene expression induced by anticancer-agent exposure in gastric cancer cell lines

  • Authors:
    • Tsunehiro Takahashi
    • Yoshiro Saikawa
    • Rieko Nakamura
    • Koshi Kumagai
    • Hiroya Takeuchi
    • Tetsuro Kubota
    • Yuko Kitagawa

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, School of Medicine, Keio University, Tokyo 160-8582, Japan
  • Pages: 451-459
    |
    Published online on: February 1, 2009
       https://doi.org/10.3892/or_00000244
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Abstract

The prognosis for advanced gastric cancer remains very poor due to the limited effectiveness of chemotherapy agents. The range in efficacy of these chemotherapy agents is likely the result of various factors including gene expression. In addition, the emergence of drug resistance during chemotherapy can result in the undesirable outcome of patients experiencing the side effects of chemotherapy without benefiting in terms of tumor response. Gene expression profiling provides a unique opportunity to gain insight into the development of different types of gastric cancer. We applied the TaqMan low density array to investigate the expression of 96 genes in four gastric cancer cell lines (TMK-1, MKN-45, MKN-74 and CDDP-resistant MKN-74). The cell lines displayed different patterns of gene expression alteration after exposure to the chemotherapeutic drugs cisplatin and 5-fluorouracil. We also established that cisplatin-resistant MKN-74 cells do not show the same gene expression patterns as the parental MKN-74 cell line at 0, 8 and 24 h after CDDP exposure. This study reveals the underlying complexity of biological and pathological events and could, perhaps, contribute to new experimental protocols or treatments that would achieve a consistent and desirable outcome of chemotherapy.

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Copy and paste a formatted citation
Spandidos Publications style
Takahashi T, Saikawa Y, Nakamura R, Kumagai K, Takeuchi H, Kubota T and Kitagawa Y: Dynamic alteration of gene expression induced by anticancer-agent exposure in gastric cancer cell lines. Oncol Rep 21: 451-459, 2009.
APA
Takahashi, T., Saikawa, Y., Nakamura, R., Kumagai, K., Takeuchi, H., Kubota, T., & Kitagawa, Y. (2009). Dynamic alteration of gene expression induced by anticancer-agent exposure in gastric cancer cell lines. Oncology Reports, 21, 451-459. https://doi.org/10.3892/or_00000244
MLA
Takahashi, T., Saikawa, Y., Nakamura, R., Kumagai, K., Takeuchi, H., Kubota, T., Kitagawa, Y."Dynamic alteration of gene expression induced by anticancer-agent exposure in gastric cancer cell lines". Oncology Reports 21.2 (2009): 451-459.
Chicago
Takahashi, T., Saikawa, Y., Nakamura, R., Kumagai, K., Takeuchi, H., Kubota, T., Kitagawa, Y."Dynamic alteration of gene expression induced by anticancer-agent exposure in gastric cancer cell lines". Oncology Reports 21, no. 2 (2009): 451-459. https://doi.org/10.3892/or_00000244
Copy and paste a formatted citation
x
Spandidos Publications style
Takahashi T, Saikawa Y, Nakamura R, Kumagai K, Takeuchi H, Kubota T and Kitagawa Y: Dynamic alteration of gene expression induced by anticancer-agent exposure in gastric cancer cell lines. Oncol Rep 21: 451-459, 2009.
APA
Takahashi, T., Saikawa, Y., Nakamura, R., Kumagai, K., Takeuchi, H., Kubota, T., & Kitagawa, Y. (2009). Dynamic alteration of gene expression induced by anticancer-agent exposure in gastric cancer cell lines. Oncology Reports, 21, 451-459. https://doi.org/10.3892/or_00000244
MLA
Takahashi, T., Saikawa, Y., Nakamura, R., Kumagai, K., Takeuchi, H., Kubota, T., Kitagawa, Y."Dynamic alteration of gene expression induced by anticancer-agent exposure in gastric cancer cell lines". Oncology Reports 21.2 (2009): 451-459.
Chicago
Takahashi, T., Saikawa, Y., Nakamura, R., Kumagai, K., Takeuchi, H., Kubota, T., Kitagawa, Y."Dynamic alteration of gene expression induced by anticancer-agent exposure in gastric cancer cell lines". Oncology Reports 21, no. 2 (2009): 451-459. https://doi.org/10.3892/or_00000244
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