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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2009 Volume 21 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2009 Volume 21 Issue 2

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Article

Knockdown of the novel proteasome subunit Adrm1 located on the 20q13 amplicon inhibits colorectal cancer cell migration, survival and tumorigenicity

  • Authors:
    • Wei Chen
    • Xiao-Tong Hu
    • Qing-Lan Shi
    • Fu-Biao Zhang
    • Chao He

  • View Affiliations / Copyright

    Affiliations: Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Zhejiang 310016, P.R. China
  • Pages: 531-537
    |
    Published online on: February 1, 2009
       https://doi.org/10.3892/or_00000254
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Abstract

The novel proteasome subunit Adrm1 located on the 20q13 amplicon was differentially expressed in colorectal cancer by semiquantitative RT-PCR. Adrm1 mRNA was overexpressed in 46.2% (18/39) colorectal cancer tissues compared to their matched normal mucosa and significantly correlated with lymph node metastasis of colorectal cancer (P=0.037). Knockdown of Adrm1 by shRNA in human colon carcinoma RKO cells inhibited their anchorage-independent growth, cell migration as well as cell proliferation through inducing apoptosis and cell cycle arrest at the G1 phase. In addition, stable RNA interference of Adrm1 gene synergistic with 5-Fu treatment suppressed RKO cell growth in vitro. Collectively, these data suggested that Adrm1 is potentially oncogenic and may play an important role in colon tumorigenesis. Regiment with combined application of Adrm1 RNA interference and chemotherapy may emerge as a novel therapeutic strategy for Adrm1 overexpressed colorectal cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Chen W, Hu X, Shi Q, Zhang F and He C: Knockdown of the novel proteasome subunit Adrm1 located on the 20q13 amplicon inhibits colorectal cancer cell migration, survival and tumorigenicity. Oncol Rep 21: 531-537, 2009.
APA
Chen, W., Hu, X., Shi, Q., Zhang, F., & He, C. (2009). Knockdown of the novel proteasome subunit Adrm1 located on the 20q13 amplicon inhibits colorectal cancer cell migration, survival and tumorigenicity. Oncology Reports, 21, 531-537. https://doi.org/10.3892/or_00000254
MLA
Chen, W., Hu, X., Shi, Q., Zhang, F., He, C."Knockdown of the novel proteasome subunit Adrm1 located on the 20q13 amplicon inhibits colorectal cancer cell migration, survival and tumorigenicity". Oncology Reports 21.2 (2009): 531-537.
Chicago
Chen, W., Hu, X., Shi, Q., Zhang, F., He, C."Knockdown of the novel proteasome subunit Adrm1 located on the 20q13 amplicon inhibits colorectal cancer cell migration, survival and tumorigenicity". Oncology Reports 21, no. 2 (2009): 531-537. https://doi.org/10.3892/or_00000254
Copy and paste a formatted citation
x
Spandidos Publications style
Chen W, Hu X, Shi Q, Zhang F and He C: Knockdown of the novel proteasome subunit Adrm1 located on the 20q13 amplicon inhibits colorectal cancer cell migration, survival and tumorigenicity. Oncol Rep 21: 531-537, 2009.
APA
Chen, W., Hu, X., Shi, Q., Zhang, F., & He, C. (2009). Knockdown of the novel proteasome subunit Adrm1 located on the 20q13 amplicon inhibits colorectal cancer cell migration, survival and tumorigenicity. Oncology Reports, 21, 531-537. https://doi.org/10.3892/or_00000254
MLA
Chen, W., Hu, X., Shi, Q., Zhang, F., He, C."Knockdown of the novel proteasome subunit Adrm1 located on the 20q13 amplicon inhibits colorectal cancer cell migration, survival and tumorigenicity". Oncology Reports 21.2 (2009): 531-537.
Chicago
Chen, W., Hu, X., Shi, Q., Zhang, F., He, C."Knockdown of the novel proteasome subunit Adrm1 located on the 20q13 amplicon inhibits colorectal cancer cell migration, survival and tumorigenicity". Oncology Reports 21, no. 2 (2009): 531-537. https://doi.org/10.3892/or_00000254
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