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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2009 Volume 21 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Methanol extract of Elaeagnus glabra, a Korean medicinal plant, inhibits HT1080 tumor cell invasion

  • Authors:
    • Li-Hua Li
    • In Kyu Baek
    • Jin Hee Kim
    • Kyung Ho Kang
    • Yang Seok Koh
    • Young Do Jung
    • Chol Kyoon Cho
    • Seok-Yong Choi
    • Boo Ahn Shin

  • View Affiliations / Copyright

    Affiliations: The Brain Korea 21 Project, Center for Biomedical Human Resources, Gwangju 501-190, Korea
  • Pages: 559-563
    |
    Published online on: February 1, 2009
       https://doi.org/10.3892/or_00000257
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Abstract

Elaeagnus glabra (Thunb.), an evergreen shrub with alternate leaves, has been used as a medicinal plant in Korea. Since many plant-derived molecules have inhibitory effects on tumor cell invasion, primarily via suppression of the activity of matrix metalloproteinases (MMPs), we investigated the effect of the methanol extract of E. glabra on tumor cell invasion. The invasiveness of HT1080 human fibrosarcoma cells were reduced in a dose-dependent manner following 24 h treatment of up to 200 µg/ml of the E. glabra extract, at which concentration no cytotoxicity occurred. Furthermore, gelatinolytic activities, and the protein and mRNA levels of MMP-2 and MMP-9 were also suppressed with increasing concentrations of the extract. Given that MMP-2 and MMP-9 are instrumental in tumor cell invasion, it is very likely that the reduction in tumor cell invasion by E. glabra extract is a consequence, at least in part, of suppressed expression of both MMP-2 and MMP-9. Isolation of a molecule(s) responsible for the extract inhibition of tumor cell invasion would pave the way for the development of a new generation of metastasis inhibitors.

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Copy and paste a formatted citation
Spandidos Publications style
Li L, Baek IK, Kim JH, Kang KH, Koh YS, Jung YD, Cho CK, Choi S and Shin BA: Methanol extract of Elaeagnus glabra, a Korean medicinal plant, inhibits HT1080 tumor cell invasion. Oncol Rep 21: 559-563, 2009.
APA
Li, L., Baek, I.K., Kim, J.H., Kang, K.H., Koh, Y.S., Jung, Y.D. ... Shin, B.A. (2009). Methanol extract of Elaeagnus glabra, a Korean medicinal plant, inhibits HT1080 tumor cell invasion. Oncology Reports, 21, 559-563. https://doi.org/10.3892/or_00000257
MLA
Li, L., Baek, I. K., Kim, J. H., Kang, K. H., Koh, Y. S., Jung, Y. D., Cho, C. K., Choi, S., Shin, B. A."Methanol extract of Elaeagnus glabra, a Korean medicinal plant, inhibits HT1080 tumor cell invasion". Oncology Reports 21.2 (2009): 559-563.
Chicago
Li, L., Baek, I. K., Kim, J. H., Kang, K. H., Koh, Y. S., Jung, Y. D., Cho, C. K., Choi, S., Shin, B. A."Methanol extract of Elaeagnus glabra, a Korean medicinal plant, inhibits HT1080 tumor cell invasion". Oncology Reports 21, no. 2 (2009): 559-563. https://doi.org/10.3892/or_00000257
Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Baek IK, Kim JH, Kang KH, Koh YS, Jung YD, Cho CK, Choi S and Shin BA: Methanol extract of Elaeagnus glabra, a Korean medicinal plant, inhibits HT1080 tumor cell invasion. Oncol Rep 21: 559-563, 2009.
APA
Li, L., Baek, I.K., Kim, J.H., Kang, K.H., Koh, Y.S., Jung, Y.D. ... Shin, B.A. (2009). Methanol extract of Elaeagnus glabra, a Korean medicinal plant, inhibits HT1080 tumor cell invasion. Oncology Reports, 21, 559-563. https://doi.org/10.3892/or_00000257
MLA
Li, L., Baek, I. K., Kim, J. H., Kang, K. H., Koh, Y. S., Jung, Y. D., Cho, C. K., Choi, S., Shin, B. A."Methanol extract of Elaeagnus glabra, a Korean medicinal plant, inhibits HT1080 tumor cell invasion". Oncology Reports 21.2 (2009): 559-563.
Chicago
Li, L., Baek, I. K., Kim, J. H., Kang, K. H., Koh, Y. S., Jung, Y. D., Cho, C. K., Choi, S., Shin, B. A."Methanol extract of Elaeagnus glabra, a Korean medicinal plant, inhibits HT1080 tumor cell invasion". Oncology Reports 21, no. 2 (2009): 559-563. https://doi.org/10.3892/or_00000257
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