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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2009 Volume 21 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Effects of two organotin(IV)(sulfonatophenyl)porphinates on MAPKs and on the growth of A375 human melanoma cells

  • Authors:
    • Maria Assunta Costa
    • Letizia Gulino
    • Lorenzo Pellerito
    • Tiziana Fiore
    • Claudia Pellerito
    • Giovanna Barbieri

  • View Affiliations / Copyright

    Affiliations: Istituto di Biomedicina e Immunologia Molecolare ‘Alberto Monroy’, Consiglio Nazionale delle Ricerche (CNR), 90146 Palermo, Italy. costama@ibim.cnr.it
  • Pages: 593-599
    |
    Published online on: March 1, 2009
       https://doi.org/10.3892/or_00000261
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Abstract

Previously we showed apoptotic induction in A375 human melanoma cells using two complexes of the meso-tetra(4-sulfonatophenyl)porphinate (TPPS), (Bu2Sn)2TPPS and (Bu3Sn)4TPPS. To understand how these compounds activate apoptosis in melanoma cells we studied MAPKs and the (Bu2Sn)2TPPS and (Bu3Sn)4TPPS cellular uptake. Western blotting experiments showed activated protein kinases ERK 1/2, JNK and p38 in 10 µM (Bu2Sn)2TPPS- and 1 µM (Bu3Sn)4TPPS-treated melanoma cells, which suggests that the three MAP kinases are involved in the apoptotic death of A375-treated cells. By taking advantage of the porphyrin fluorescence, we found a fast concentration of (Bu2Sn)2TPPS and (Bu3Sn)4TPPS in the nucleus and in the nucleoli compared to TPPS. A significantly reduced growth of A375 human melanoma cells was also observed after only 48 h treatment by using 500 nM of (Bu2Sn)2TPPS or 80 nM of (Bu3Sn)4TPPS. A strong slowdown of cell growth and loss of cell-cell interactions were visible by in vitro wound repair assay.

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Copy and paste a formatted citation
Spandidos Publications style
Costa MA, Gulino L, Pellerito L, Fiore T, Pellerito C and Barbieri G: Effects of two organotin(IV)(sulfonatophenyl)porphinates on MAPKs and on the growth of A375 human melanoma cells. Oncol Rep 21: 593-599, 2009.
APA
Costa, M.A., Gulino, L., Pellerito, L., Fiore, T., Pellerito, C., & Barbieri, G. (2009). Effects of two organotin(IV)(sulfonatophenyl)porphinates on MAPKs and on the growth of A375 human melanoma cells. Oncology Reports, 21, 593-599. https://doi.org/10.3892/or_00000261
MLA
Costa, M. A., Gulino, L., Pellerito, L., Fiore, T., Pellerito, C., Barbieri, G."Effects of two organotin(IV)(sulfonatophenyl)porphinates on MAPKs and on the growth of A375 human melanoma cells". Oncology Reports 21.3 (2009): 593-599.
Chicago
Costa, M. A., Gulino, L., Pellerito, L., Fiore, T., Pellerito, C., Barbieri, G."Effects of two organotin(IV)(sulfonatophenyl)porphinates on MAPKs and on the growth of A375 human melanoma cells". Oncology Reports 21, no. 3 (2009): 593-599. https://doi.org/10.3892/or_00000261
Copy and paste a formatted citation
x
Spandidos Publications style
Costa MA, Gulino L, Pellerito L, Fiore T, Pellerito C and Barbieri G: Effects of two organotin(IV)(sulfonatophenyl)porphinates on MAPKs and on the growth of A375 human melanoma cells. Oncol Rep 21: 593-599, 2009.
APA
Costa, M.A., Gulino, L., Pellerito, L., Fiore, T., Pellerito, C., & Barbieri, G. (2009). Effects of two organotin(IV)(sulfonatophenyl)porphinates on MAPKs and on the growth of A375 human melanoma cells. Oncology Reports, 21, 593-599. https://doi.org/10.3892/or_00000261
MLA
Costa, M. A., Gulino, L., Pellerito, L., Fiore, T., Pellerito, C., Barbieri, G."Effects of two organotin(IV)(sulfonatophenyl)porphinates on MAPKs and on the growth of A375 human melanoma cells". Oncology Reports 21.3 (2009): 593-599.
Chicago
Costa, M. A., Gulino, L., Pellerito, L., Fiore, T., Pellerito, C., Barbieri, G."Effects of two organotin(IV)(sulfonatophenyl)porphinates on MAPKs and on the growth of A375 human melanoma cells". Oncology Reports 21, no. 3 (2009): 593-599. https://doi.org/10.3892/or_00000261
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