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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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March 2009 Volume 21 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway

  • Authors:
    • Chu-Chung Chou
    • Yao-Chung Wu
    • Yu-Fen Wang
    • Ming-Jen Chou
    • Shou-Jen Kuo
    • Dar-Ren Chen

  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, Changhua Christian Hospital, Changhua, Taiwan, R.O.C.
  • Pages: 665-671
    |
    Published online on: March 1, 2009
       https://doi.org/10.3892/or_00000269
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Abstract

Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a significant pungent ingredient in a variety of red peppers of the genus Capsicum, is a type of vanilloid. It has been shown to exert biological activities (anticarcinogenic, antimutagenic and chemopreventive) in many cancer cell lines. It was found that capsaicin induces dose-dependent growth inhibition of MCF-7 cells, which does not express caspase-3. In this study, we investigated the molecular mechanism of capsaicin-induced apoptosis in MCF-7 cells. Treatment with capsaicin for 24 h resulted in dose-dependent apoptosis in these cells. After the addition of capsaicin, the levels of reactive oxygen species were reduced slightly in the earlier stage of treatment. Interestingly, an elevation of intracellular calcium ion concentration was detected in the MCF-7 cells. In time course and dosage studies, the mitochondrial membrane potential of MCF-7 cells decreased. However, the change was not significant. It is worth noting that the apoptosis-inducing factor translocated into the cytosol and nucleus from the mitochondria. Our results suggest that capsaicin induces cellular apoptosis through a caspase-independent pathway in MCF-7 cells, and that reactive oxygen species and intracellular calcium ion fluctuation has a minimal role in the process.

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Copy and paste a formatted citation
Spandidos Publications style
Chou C, Wu Y, Wang Y, Chou M, Kuo S and Chen D: Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway. Oncol Rep 21: 665-671, 2009.
APA
Chou, C., Wu, Y., Wang, Y., Chou, M., Kuo, S., & Chen, D. (2009). Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway. Oncology Reports, 21, 665-671. https://doi.org/10.3892/or_00000269
MLA
Chou, C., Wu, Y., Wang, Y., Chou, M., Kuo, S., Chen, D."Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway". Oncology Reports 21.3 (2009): 665-671.
Chicago
Chou, C., Wu, Y., Wang, Y., Chou, M., Kuo, S., Chen, D."Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway". Oncology Reports 21, no. 3 (2009): 665-671. https://doi.org/10.3892/or_00000269
Copy and paste a formatted citation
x
Spandidos Publications style
Chou C, Wu Y, Wang Y, Chou M, Kuo S and Chen D: Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway. Oncol Rep 21: 665-671, 2009.
APA
Chou, C., Wu, Y., Wang, Y., Chou, M., Kuo, S., & Chen, D. (2009). Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway. Oncology Reports, 21, 665-671. https://doi.org/10.3892/or_00000269
MLA
Chou, C., Wu, Y., Wang, Y., Chou, M., Kuo, S., Chen, D."Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway". Oncology Reports 21.3 (2009): 665-671.
Chicago
Chou, C., Wu, Y., Wang, Y., Chou, M., Kuo, S., Chen, D."Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway". Oncology Reports 21, no. 3 (2009): 665-671. https://doi.org/10.3892/or_00000269
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