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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2009 Volume 21 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Review Open Access

Mechanisms of secondary resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumours (Review)

  • Authors:
    • Alessandra Maleddu
    • Maria A. Pantaleo
    • Margherita Nannini
    • Monica Di Battista
    • Maristella Saponara
    • Cristian Lolli
    • Guido Biasco

  • View Affiliations / Copyright

    Affiliations: Institute of Hematology and Medical Oncology ‘L&A Seràgnoli’, Sant'Orsola-Malpighi Hospital, University of Bologna, I-40138 Bologna, Italy. alessandramaleddu@gmail.com
  • Pages: 1359-1366
    |
    Published online on: June 1, 2009
       https://doi.org/10.3892/or_00000361
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Abstract

Treatment of patients affected by advanced or inoperable GIST was revolutionized by the use of the tyrosine kinase inhibitors. Despite the fact that most patients have a good durable response of disease, they develop a resistance to treatments after a median time of 24 months. The acquired resistance is an emerging aspect in medical oncology especially in the era of target therapies. The aim of this review is to report all known mechanisms of secondary resistance to tyrosine kinase inhibitors and to highlight their clinical implications. In general, they may be divided in mechanisms related to the acquisition of new molecular abnormalities associated to KIT and PDGFRA receptor signalling pathway, such as the loss of KIT expression, the genomic amplification of KIT, the activation of an alternative downstream signalling pathways such as AKT/mTOR and the acquisition of new receptor mutations, and other mechanisms different to KIT/PDGFRA receptors. Future research perspectives on target therapy and early resistance evaluation are also discussed.

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Copy and paste a formatted citation
Spandidos Publications style
Maleddu A, Pantaleo MA, Nannini M, Di Battista M, Saponara M, Lolli C and Biasco G: Mechanisms of secondary resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumours (Review). Oncol Rep 21: 1359-1366, 2009.
APA
Maleddu, A., Pantaleo, M.A., Nannini, M., Di Battista, M., Saponara, M., Lolli, C., & Biasco, G. (2009). Mechanisms of secondary resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumours (Review). Oncology Reports, 21, 1359-1366. https://doi.org/10.3892/or_00000361
MLA
Maleddu, A., Pantaleo, M. A., Nannini, M., Di Battista, M., Saponara, M., Lolli, C., Biasco, G."Mechanisms of secondary resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumours (Review)". Oncology Reports 21.6 (2009): 1359-1366.
Chicago
Maleddu, A., Pantaleo, M. A., Nannini, M., Di Battista, M., Saponara, M., Lolli, C., Biasco, G."Mechanisms of secondary resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumours (Review)". Oncology Reports 21, no. 6 (2009): 1359-1366. https://doi.org/10.3892/or_00000361
Copy and paste a formatted citation
x
Spandidos Publications style
Maleddu A, Pantaleo MA, Nannini M, Di Battista M, Saponara M, Lolli C and Biasco G: Mechanisms of secondary resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumours (Review). Oncol Rep 21: 1359-1366, 2009.
APA
Maleddu, A., Pantaleo, M.A., Nannini, M., Di Battista, M., Saponara, M., Lolli, C., & Biasco, G. (2009). Mechanisms of secondary resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumours (Review). Oncology Reports, 21, 1359-1366. https://doi.org/10.3892/or_00000361
MLA
Maleddu, A., Pantaleo, M. A., Nannini, M., Di Battista, M., Saponara, M., Lolli, C., Biasco, G."Mechanisms of secondary resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumours (Review)". Oncology Reports 21.6 (2009): 1359-1366.
Chicago
Maleddu, A., Pantaleo, M. A., Nannini, M., Di Battista, M., Saponara, M., Lolli, C., Biasco, G."Mechanisms of secondary resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumours (Review)". Oncology Reports 21, no. 6 (2009): 1359-1366. https://doi.org/10.3892/or_00000361
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