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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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June 2009 Volume 21 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2009 Volume 21 Issue 6

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Article

Increased BTB-Kelch type substrate adaptor protein immunoreactivity associates with advanced stage and poor differentiation in renal cell carcinoma

  • Authors:
    • Hanna Ronkainen
    • Markku H. Vaarala
    • Saila Kauppila
    • Ylermi Soini
    • Timo K. Paavonen
    • Jenni Rask
    • Pasi Hirvikoski

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Oulu University Hospital, Oulu, 90029 OYS, Finland
  • Pages: 1519-1523
    |
    Published online on: June 1, 2009
       https://doi.org/10.3892/or_00000383
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Abstract

Renal cell carcinoma (RCC) is a malignancy with increasing incidence. Despite the well-known prognostic factors - the stage, grade and histological subtype - the clinical course of RCC can seem quite random. The aim of this study was to evaluate markers of the oxidative system as candidate prognostic factors for RCC. Our study population consisted of 152 patients who underwent operation for RCC between 1990 and 1999. The tumours were examined with three immunohistochemical markers of the oxidative system, thioredoxin (Trx), NF-E2-related factor (Nfr2) and BTB-Kelch type substrate adaptor protein (Keap1). Cytoplasmic Keap1 staining was related to poorer prognosis in renal cancer-specific survival. The difference was statistically significant (P=0.02). Keap1 staining was associated with a more advanced stage and a higher nuclear grade. Cytoplasmic Trx staining was associated with a trend of better prognosis in renal cancer-specific survival. Nfr2 staining was not a prognostic factor in renal cancer-specific survival. In RCC, Keap1 is associated with a more advanced disease, a higher grade and a poorer prognosis.

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Copy and paste a formatted citation
Spandidos Publications style
Ronkainen H, Vaarala MH, Kauppila S, Soini Y, Paavonen TK, Rask J and Hirvikoski P: Increased BTB-Kelch type substrate adaptor protein immunoreactivity associates with advanced stage and poor differentiation in renal cell carcinoma. Oncol Rep 21: 1519-1523, 2009.
APA
Ronkainen, H., Vaarala, M.H., Kauppila, S., Soini, Y., Paavonen, T.K., Rask, J., & Hirvikoski, P. (2009). Increased BTB-Kelch type substrate adaptor protein immunoreactivity associates with advanced stage and poor differentiation in renal cell carcinoma. Oncology Reports, 21, 1519-1523. https://doi.org/10.3892/or_00000383
MLA
Ronkainen, H., Vaarala, M. H., Kauppila, S., Soini, Y., Paavonen, T. K., Rask, J., Hirvikoski, P."Increased BTB-Kelch type substrate adaptor protein immunoreactivity associates with advanced stage and poor differentiation in renal cell carcinoma". Oncology Reports 21.6 (2009): 1519-1523.
Chicago
Ronkainen, H., Vaarala, M. H., Kauppila, S., Soini, Y., Paavonen, T. K., Rask, J., Hirvikoski, P."Increased BTB-Kelch type substrate adaptor protein immunoreactivity associates with advanced stage and poor differentiation in renal cell carcinoma". Oncology Reports 21, no. 6 (2009): 1519-1523. https://doi.org/10.3892/or_00000383
Copy and paste a formatted citation
x
Spandidos Publications style
Ronkainen H, Vaarala MH, Kauppila S, Soini Y, Paavonen TK, Rask J and Hirvikoski P: Increased BTB-Kelch type substrate adaptor protein immunoreactivity associates with advanced stage and poor differentiation in renal cell carcinoma. Oncol Rep 21: 1519-1523, 2009.
APA
Ronkainen, H., Vaarala, M.H., Kauppila, S., Soini, Y., Paavonen, T.K., Rask, J., & Hirvikoski, P. (2009). Increased BTB-Kelch type substrate adaptor protein immunoreactivity associates with advanced stage and poor differentiation in renal cell carcinoma. Oncology Reports, 21, 1519-1523. https://doi.org/10.3892/or_00000383
MLA
Ronkainen, H., Vaarala, M. H., Kauppila, S., Soini, Y., Paavonen, T. K., Rask, J., Hirvikoski, P."Increased BTB-Kelch type substrate adaptor protein immunoreactivity associates with advanced stage and poor differentiation in renal cell carcinoma". Oncology Reports 21.6 (2009): 1519-1523.
Chicago
Ronkainen, H., Vaarala, M. H., Kauppila, S., Soini, Y., Paavonen, T. K., Rask, J., Hirvikoski, P."Increased BTB-Kelch type substrate adaptor protein immunoreactivity associates with advanced stage and poor differentiation in renal cell carcinoma". Oncology Reports 21, no. 6 (2009): 1519-1523. https://doi.org/10.3892/or_00000383
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