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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2010 Volume 23 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Gastrointestinal stromal tumor and other primary metachronous or synchronous neoplasms as a suspicion criterion for syndromic setting

  • Authors:
    • Giovanni Ponti
    • Gabriele Luppi
    • Davide Martorana
    • Giulio Rossi
    • Lorena Losi
    • Federica Bertolini
    • Giuliana Sartori
    • Giovanni Pellacani
    • Stefania Seidenari
    • Elisa Boni
    • Tauro Maria Neri
    • Enrico Silini
    • Elisa Tamburini
    • Antonio Maiorana
    • Pier Franco Conte
  • View Affiliations / Copyright

    Affiliations: Department of Oncology and Haematology, University of Modena and Reggio Emilia, 41100 Modena, Italy. ponti.giovanni@unimo.it
  • Pages: 437-444
    |
    Published online on: February 1, 2010
       https://doi.org/10.3892/or_00000653
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Abstract

Gastrointestinal stromal tumors (GISTs) may be sporadic or inherited. Although KIT and PDGFRA activating mutations are the oncogenic mechanisms in most sporadic and inherited GISTs, a small subset of GISTs are negative for both. Besides the classical Familial GIST Syndrome, GIST can occur as part of multi-neoplastic disease. The present study was designed to analyze the synchronous and metachronous tumors developed among GIST patients assessed by our institution for GIST Syndrome setting recognition. Patients (n=141) with primary GIST (77 men and 64 women) were recruited between 1988 and 2007 and their clinical and pathological records were reviewed. Mutation analysis of KIT, PDGFRA, NF1 and MMR genes was performed on somatic and peripheral blood DNA. GISTs occurred associated with other primary malignancies in 46 of 141 (32.6%) patients. The most common neoplasms were gastrointestinal and genitourinary. A novel exon 6 germline large deletion of NF1 was identified in the NF1/GIST kindred. The development of GIST associated with other neoplasms is common and diagnosis of peculiar benign associated-neoplasms warrants the search for familial cancer susceptibility. In particular, syndromic or familial settings have to be suspected in the presence of neurofibroma or lung chordoma in C-KIT and PDGFRA negative GIST patients.

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Copy and paste a formatted citation
Spandidos Publications style
Ponti G, Luppi G, Martorana D, Rossi G, Losi L, Bertolini F, Sartori G, Pellacani G, Seidenari S, Boni E, Boni E, et al: Gastrointestinal stromal tumor and other primary metachronous or synchronous neoplasms as a suspicion criterion for syndromic setting. Oncol Rep 23: 437-444, 2010.
APA
Ponti, G., Luppi, G., Martorana, D., Rossi, G., Losi, L., Bertolini, F. ... Conte, P.F. (2010). Gastrointestinal stromal tumor and other primary metachronous or synchronous neoplasms as a suspicion criterion for syndromic setting. Oncology Reports, 23, 437-444. https://doi.org/10.3892/or_00000653
MLA
Ponti, G., Luppi, G., Martorana, D., Rossi, G., Losi, L., Bertolini, F., Sartori, G., Pellacani, G., Seidenari, S., Boni, E., Neri, T. M., Silini, E., Tamburini, E., Maiorana, A., Conte, P. F."Gastrointestinal stromal tumor and other primary metachronous or synchronous neoplasms as a suspicion criterion for syndromic setting". Oncology Reports 23.2 (2010): 437-444.
Chicago
Ponti, G., Luppi, G., Martorana, D., Rossi, G., Losi, L., Bertolini, F., Sartori, G., Pellacani, G., Seidenari, S., Boni, E., Neri, T. M., Silini, E., Tamburini, E., Maiorana, A., Conte, P. F."Gastrointestinal stromal tumor and other primary metachronous or synchronous neoplasms as a suspicion criterion for syndromic setting". Oncology Reports 23, no. 2 (2010): 437-444. https://doi.org/10.3892/or_00000653
Copy and paste a formatted citation
x
Spandidos Publications style
Ponti G, Luppi G, Martorana D, Rossi G, Losi L, Bertolini F, Sartori G, Pellacani G, Seidenari S, Boni E, Boni E, et al: Gastrointestinal stromal tumor and other primary metachronous or synchronous neoplasms as a suspicion criterion for syndromic setting. Oncol Rep 23: 437-444, 2010.
APA
Ponti, G., Luppi, G., Martorana, D., Rossi, G., Losi, L., Bertolini, F. ... Conte, P.F. (2010). Gastrointestinal stromal tumor and other primary metachronous or synchronous neoplasms as a suspicion criterion for syndromic setting. Oncology Reports, 23, 437-444. https://doi.org/10.3892/or_00000653
MLA
Ponti, G., Luppi, G., Martorana, D., Rossi, G., Losi, L., Bertolini, F., Sartori, G., Pellacani, G., Seidenari, S., Boni, E., Neri, T. M., Silini, E., Tamburini, E., Maiorana, A., Conte, P. F."Gastrointestinal stromal tumor and other primary metachronous or synchronous neoplasms as a suspicion criterion for syndromic setting". Oncology Reports 23.2 (2010): 437-444.
Chicago
Ponti, G., Luppi, G., Martorana, D., Rossi, G., Losi, L., Bertolini, F., Sartori, G., Pellacani, G., Seidenari, S., Boni, E., Neri, T. M., Silini, E., Tamburini, E., Maiorana, A., Conte, P. F."Gastrointestinal stromal tumor and other primary metachronous or synchronous neoplasms as a suspicion criterion for syndromic setting". Oncology Reports 23, no. 2 (2010): 437-444. https://doi.org/10.3892/or_00000653
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