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Oncology Reports
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Print ISSN: 1021-335X Online ISSN: 1791-2431
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February 2010 Volume 23 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Induction of apoptosis by the angucyclinone antibiotic chemomicin in human tumor cells

  • Authors:
    • Yong Li
    • Ningning Han
    • Ning Gao
    • Rong Xu
    • Chenghang Sun
    • Diandong Li
    • Qiyang He

  • View Affiliations / Copyright

    Affiliations: Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, P.R. China
  • Pages: 477-483
    |
    Published online on: February 1, 2010
       https://doi.org/10.3892/or_00000658
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Abstract

Chemomicin (CHM), an angucyclinone antibiotic extracted from the fermentation broth of Nocardia Mediterranei subsp. Kanglensis 1747-64, shows immunosuppressive activity. However, whether it can inhibit growth of tumor cells remains elusive. In the present study, we show that CHM potently inhibited the proliferations of eight various types of human tumor cell lines and non-cross resistant to multidrug-resistant cells. In contrast to action of doxorubicin, the generation of reactive oxygen species was observed as early as 30 min after addition of CHM and its process did not involve iron. The apoptotic cells with chromatin condensation and Annexin V staining markedly increased after the human hepatoma HepG2 was exposed to 1, or 2 µg/ml CHM for 24 h. In the CHM-induced apoptosis, robust increment of p53 expression, activation of caspase-3, -7, -8, -9, cleavage of PARP and the phosphorylation of p38 and JNK, were detected by Western blot analysis. Further investigation revealed the disruption of mitochondrial membrane potential in the cells with CHM incubation for 4 h. Taken together, the results demonstrated that potent proliferation inhibitory effect of CHM on tumor cells is due to activation of the apoptotic pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Han N, Gao N, Xu R, Sun C, Li D and He Q: Induction of apoptosis by the angucyclinone antibiotic chemomicin in human tumor cells. Oncol Rep 23: 477-483, 2010.
APA
Li, Y., Han, N., Gao, N., Xu, R., Sun, C., Li, D., & He, Q. (2010). Induction of apoptosis by the angucyclinone antibiotic chemomicin in human tumor cells. Oncology Reports, 23, 477-483. https://doi.org/10.3892/or_00000658
MLA
Li, Y., Han, N., Gao, N., Xu, R., Sun, C., Li, D., He, Q."Induction of apoptosis by the angucyclinone antibiotic chemomicin in human tumor cells". Oncology Reports 23.2 (2010): 477-483.
Chicago
Li, Y., Han, N., Gao, N., Xu, R., Sun, C., Li, D., He, Q."Induction of apoptosis by the angucyclinone antibiotic chemomicin in human tumor cells". Oncology Reports 23, no. 2 (2010): 477-483. https://doi.org/10.3892/or_00000658
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Han N, Gao N, Xu R, Sun C, Li D and He Q: Induction of apoptosis by the angucyclinone antibiotic chemomicin in human tumor cells. Oncol Rep 23: 477-483, 2010.
APA
Li, Y., Han, N., Gao, N., Xu, R., Sun, C., Li, D., & He, Q. (2010). Induction of apoptosis by the angucyclinone antibiotic chemomicin in human tumor cells. Oncology Reports, 23, 477-483. https://doi.org/10.3892/or_00000658
MLA
Li, Y., Han, N., Gao, N., Xu, R., Sun, C., Li, D., He, Q."Induction of apoptosis by the angucyclinone antibiotic chemomicin in human tumor cells". Oncology Reports 23.2 (2010): 477-483.
Chicago
Li, Y., Han, N., Gao, N., Xu, R., Sun, C., Li, D., He, Q."Induction of apoptosis by the angucyclinone antibiotic chemomicin in human tumor cells". Oncology Reports 23, no. 2 (2010): 477-483. https://doi.org/10.3892/or_00000658
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