Open Access

Recurrent bullous pemphigoid: A case report and literature review

  • Authors:
    • Karthik Rajaram Mohan
    • Sasti Priya Govindasamy Sugumar
    • Saramma Mathew Fenn
    • Ravikumar Pethagounder Thangavelu
  • View Affiliations

  • Published online on: January 2, 2023     https://doi.org/10.3892/wasj.2023.185
  • Article Number: 8
  • Copyright: © Rajaram Mohan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to enhance the current understanding of the etiopathogenesis, predisposing factors, clinical features and current management modalities for bullous pemphigoid (BP). BP is a chronic autoimmune disorder mediated by antibodies targeting BP180, a type XVII collagen (BPAG2), and BP230, a hemidesmosome protein located in basal keratinocytes, resulting in the formation of subepithelial blisters and multiple chronic oral ulcers, which heal without scarring, as well as urticarial lesions on the extremities. The BP lesions occur in the oral cavity following the onset of pruritic papules in the extremities. The present study describes the case of a patient with recurrent BP who was hypertensive and treated with amlodipine. In addition, a detailed search was performed on the PubMed database by searching the key word ‘bullous pemphigoid’; ~33 articles were selected which were published from 2005‑2022 for inclusion and discussion in the literature review. Studies published prior to 2005 were excluded. The anti‑hypertensive drug, amlodipine, has a high propensity for BP lesions. However, caution needs to be taken when prescribing amlodipine for hypertension. The occurrence of BP must not be overlooked, and the oral physician must seek a complete detailed drug history and clinical examination, which will aid in the diagnosis of BP. BP lesions are usually multiple and have a chronicity and usually affects the oral mucosa, upper torso and arms. There is a period of exacerbations and remissions. On the whole, the present study provides insight into the etiology, predisposing risk factors, etiopathogenesis, clinical features and management modalities for BP.

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January-February 2023
Volume 5 Issue 1

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Spandidos Publications style
Rajaram Mohan K, Govindasamy Sugumar SP, Fenn SM and Pethagounder Thangavelu R: Recurrent bullous pemphigoid: A case report and literature review. World Acad Sci J 5: 8, 2023
APA
Rajaram Mohan, K., Govindasamy Sugumar, S.P., Fenn, S.M., & Pethagounder Thangavelu, R. (2023). Recurrent bullous pemphigoid: A case report and literature review. World Academy of Sciences Journal, 5, 8. https://doi.org/10.3892/wasj.2023.185
MLA
Rajaram Mohan, K., Govindasamy Sugumar, S. P., Fenn, S. M., Pethagounder Thangavelu, R."Recurrent bullous pemphigoid: A case report and literature review". World Academy of Sciences Journal 5.1 (2023): 8.
Chicago
Rajaram Mohan, K., Govindasamy Sugumar, S. P., Fenn, S. M., Pethagounder Thangavelu, R."Recurrent bullous pemphigoid: A case report and literature review". World Academy of Sciences Journal 5, no. 1 (2023): 8. https://doi.org/10.3892/wasj.2023.185